Anti-annexin V Antibodies in Women with Recurrent Miscarriage

Clinical Medicine Insights-Reproductive Health Pub Date : 2010-01-01 DOI:10.4137/CMRH.S5835

M. El-Gharib, T. M. Elhawary, S. H. Elshourbagy, M. Morad

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引用次数: 3

Abstract

Objective To determine the role of anti-annexin V antibodies (a-A5) as an etiologic factor in recurrent pregnancy failure. Study design Prospective observational study. Material and methods The study included ninety first trimester pregnant women who had a history of unexplained recurrent miscarriage (group I) with ninety well-matched pregnant women with a history of normal reproductive outcome allocated as control group (GII) and another ninety nonpregnant women (GIII). Sera from all women controls were analyzed for anti-annexin antibody measured by Elisa. Results The mean value of a-A5 was 11.37 ± 6.78, 7.7 ± 1.40 and 6.20 ± 0.95 ng/ml in groups I, II and III respectively. There was a significant increase in the mean value a-A5 among women with a history of recurrent miscarriage, compared with controls. The mean value was 13.92 ± 2.42 ng/ml among patients with unfavourable outcome, compared with a corresponding value of 6.95 V 0.58 ng/ml among women with favourable outcome. The receiver operator characteristic curve revealed that the cutoff value of a-A5 was 8.61 ng/ml. Conclusion This study emphasizes the relationship between anti-annexin V antibodies and recurrent miscarriage.

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反复流产妇女的抗膜联蛋白V抗体

目的探讨抗膜联蛋白V抗体(a-A5)在反复妊娠失败中的作用。研究设计前瞻性观察性研究。材料与方法本研究纳入90例有不明原因复发性流产史的妊娠早期妇女(I组)，90例生育结果正常且匹配良好的孕妇作为对照组(GII)，另外90例非妊娠妇女(GIII)。所有对照女性血清均采用Elisa法检测抗膜联蛋白抗体。结果a-A5在I、II和III组的平均值分别为11.37±6.78、7.7±1.40和6.20±0.95 ng/ml。与对照组相比，有复发性流产史的妇女a- a5的平均值显著增加。不良结局患者的平均值为13.92±2.42 ng/ml，而良好结局女性的相应值为6.95 V 0.58 ng/ml。接收算子特征曲线显示a-A5的截止值为8.61 ng/ml。结论本研究强调抗膜联蛋白V抗体与复发性流产的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Medicine Insights-Reproductive Health OBSTETRICS & GYNECOLOGY-

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Clinical Medicine Insights: Reproductive Health is a peer reviewed; open access journal, which covers all aspects of Reproduction: Gynecology, Obstetrics, and Infertility, spanning both male and female issues, from the physical to the psychological and the social, including: sex, contraception, pregnancy, childbirth, and related topics such as social and emotional impacts. It welcomes original research and review articles from across the health sciences. Clinical subjects include fertility and sterility, infertility and assisted reproduction, IVF, fertility preservation despite gonadotoxic chemo- and/or radiotherapy, pregnancy problems, PPD, infections and disease, surgery, diagnosis, menopause, HRT, pelvic floor problems, reproductive cancers and environmental impacts on reproduction, although this list is by no means exhaustive Subjects covered include, but are not limited to: • fertility and sterility, • infertility and ART, • ART/IVF, • fertility preservation despite gonadotoxic chemo- and/or radiotherapy, • pregnancy problems, • Postpartum depression • Infections and disease, • Gyn/Ob surgery, • diagnosis, • Contraception • Premenstrual tension • Gynecologic Oncology • reproductive cancers • environmental impacts on reproduction, • Obstetrics/Gynaecology • Women''s Health • menopause, • HRT, • pelvic floor problems, • Paediatric and adolescent gynaecology • PID