Anti-inflammatory effect of Śirīṣāvaleha prepared by two liquid media on carrageenan induced rat paw oedema model

H. Kaur, G. Ruknuddin, M. Nariya, B. Patgiri, P. Bedarkar, P. Prajapati
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Abstract

Background: Steroidal and non-steroidal anti-inflammatory agents have several limitations, due to which people are moving towards use of traditional medicines. Considering this, the current attempt is aimed to evaluate in vivo anti-inflammatory effect of a poly-herbal formulation Śirīṣāvaleha prepared in presence of water and Kanji (sour gruel). Kanji is anticipated to bring extraction of more principles from the raw drugs and may improve therapeutic attributes of the drug. Considering this, Kanji was used as a liquid medium for preparation of Śirīṣāvaleha and was evaluated for anti-inflammatory activity in comparison to Śirīṣāvaleha prepared with water. Materials and Methods: The activity was screened in carrageenan induced rat paw oedema model in albino rats. The raw materials were collected; authenticated and trial formulations were prepared by following standard classical guidelines. Randomly selected animals were divided into four groups of six animals each. The test drugs were administered orally at a dose of 1.8 g/kg for five days. Phenylbutazone was used as standard anti-inflammatory drug for comparison. Results: Results showed the presence of pronounced anti-inflammatory activity in Śirīṣāvaleha prepared with water (SW) followed by Śirīṣāvaleha prepared with Kanji (SK). Conclusion: Study shows that both samples of Śirīṣāvaleha have anti-inflammatory effect.
两种液体培养基制备Śirīṣāvaleha对卡拉胶致大鼠足跖水肿模型的抗炎作用
背景:甾体和非甾体抗炎药有一些局限性,因此人们正转向使用传统药物。考虑到这一点,目前的尝试旨在评估在水和汉字(酸粥)存在下制备的多草药配方Śirīṣāvaleha的体内抗炎作用。汉字有望从原始药物中提取更多的原理,并可能改善药物的治疗属性。考虑到这一点,我们将汉字作为液体介质制备Śirīṣāvaleha,并与水制备的Śirīṣāvaleha进行抗炎活性比较。材料与方法:对卡拉胶致白化大鼠足跖水肿模型进行活性筛选。收集原料;经过验证和试验的配方是按照标准的经典指导方针制备的。随机选择的动物被分成四组,每组6只。试验药物以1.8 g/kg的剂量口服5天。以苯丁酮为标准抗炎药进行比较。结果:水制Śirīṣāvaleha (SW)具有明显的抗炎活性,汉字制Śirīṣāvaleha (SK)具有明显的抗炎活性。结论:研究表明Śirīṣāvaleha两种样品均具有抗炎作用。
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