Primary ciliary dyskinesia: how to diagnose, how to treat

Abstract

characteristics of the syndrome. Underlining the diagnostic and therapeutic difficulties. Pcd symptoms include ards at the age of early – infancy, recurrent lower respiratory tract infections, chronic rhinosinusitis and otitis media, or impaired fertility. Pcd requires differentiation with atypical asthma, bronchiectasis and cystic fibrosis. diagnostic algorithm consist of cascade of tests (brush cytology/bronchoscopic samples, cilia motility evaluation, function and structure assesment with electron microscopy, immunochemical testing, genetic testing) preceded by screening tests (saccharin, measurement nno). 1. the primary ciliary dyskinesia is rarely taking under consideration in the differential diagnosis of chronic/recurrent upper respiratory tract infections. 2. available screening tests do not include target group of patients (< 12 y.o.). 3. no recommendations for the type and methods of obtaining material for testing and methods of its transportation. 4. the basic diagnostic limitation is high cost of a conclusive tests. 5. there is necessity to differentiate primary and secondary ciliary dyskinesia. 6. no general algorithm running patients diagnosed with Pcd – the mandatory introduction of standard therapy.