IMMUNOMODULATORY ROLE OF VITAMIN D: CLINICAL IMPLICATIONS IN INFECTIONS AND AUTOIMMUNE DISORDERS

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL
F. K. Alswailmi, S. I. Shah, Haleema Nawaz
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引用次数: 4

Abstract

Vitamin D exerts its well-known effects on bone health and calcium-phosphate homeostasis primarily through the vitamin D receptor signaling pathway. Vitamin D also has several extra-skeletal actions and its deficiency is not only implicated in musculoskeletal disorders, but also cardiovascular disorders, diabetes, neurodegenerative conditions and cancers. There is a growing body of research highlighting the link of vitamin D deficiency and alterations in vitamin D signaling with certain infections and autoimmune disorders although the evidence is inconsistent and inconclusive. Vitamin D has been suggested to play a fundamental role in curbing infections and mitigating autoimmune disease processes. The present review was undertaken to explore the promise of vitamin D as a protective agent and a clinically useful therapeutic adjunct against infections and autoimmune diseases and identify knowledge gaps and limitations of the available data for informing future work. An exhaustive search was conducted in established databases including Google Scholar, PubMed, Science Direct and Springer for articles published on vitamin D, immunity, infection and autoimmune disorders. All relevant articles published in the English language between the year 200 and 2020 were retrieved for writing the review. Although a considerable body of evidence highlighting the potential clinical benefits of vitamin D against the development of various autoimmune conditions and for the prevention of infections has emerged over the last decade, the findings are limited by the lack of appropriately designed randomized controlled trials which are needed to formulate precise clinical recommendations.
维生素d的免疫调节作用:感染和自身免疫性疾病的临床意义
维生素D主要通过维生素D受体信号通路对骨骼健康和磷酸钙稳态发挥其众所周知的作用。维生素D还具有多种骨骼外作用,缺乏维生素D不仅与肌肉骨骼疾病有关,还与心血管疾病、糖尿病、神经退行性疾病和癌症有关。越来越多的研究强调维生素D缺乏和维生素D信号改变与某些感染和自身免疫性疾病之间的联系,尽管证据不一致且不确定。维生素D被认为在抑制感染和减轻自身免疫性疾病过程中起着重要作用。本综述旨在探索维生素D作为预防感染和自身免疫性疾病的保护剂和临床有用的治疗辅助剂的前景,并确定现有数据的知识差距和局限性,为今后的工作提供信息。在谷歌Scholar、PubMed、Science Direct和施普林格等已建立的数据库中进行了详尽的搜索,以获取有关维生素D、免疫、感染和自身免疫性疾病的文章。检索了2000年至2020年间发表的所有相关英文文章,用于撰写综述。尽管在过去十年中出现了相当多的证据,强调维生素D对各种自身免疫性疾病的发展和预防感染的潜在临床益处,但由于缺乏适当设计的随机对照试验,需要制定精确的临床建议,这些发现受到限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gomal Journal of Medical Sciences
Gomal Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
0.60
自引率
80.00%
发文量
37
审稿时长
40 weeks
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