Role of Self-Loop in Cell-Cycle Network of Budding Yeast

S. Kinoshita, H. Yamada
{"title":"Role of Self-Loop in Cell-Cycle Network of Budding Yeast","authors":"S. Kinoshita, H. Yamada","doi":"10.4236/OJBIPHY.2019.91002","DOIUrl":null,"url":null,"abstract":"Study of network dynamics is very active area in biological and social sciences. However, the relationship between the network structure and the attractors of the dynamics has not been fully understood yet. In this study, we numerically investigated the role of degenerate self-loops on the attractors and its basin size using the budding yeast cell-cycle network model. In the network, all self-loops negatively suppress the node (self-inhibition loops) and the attractors are only fixed points, i.e. point attractors. It is found that there is a simple division rule of the state space by removing the self-loops when the attractors consist only of point attractors. The point attractor with largest basin size is robust against the change of the self-inhibition loop. Furthermore, some limit cycles of period 2 appear as new attractor when a self-activation loop is added to the original network. It is also shown that even in that case, the point attractor with largest basin size is robust.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"生物物理学期刊(英文)","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.4236/OJBIPHY.2019.91002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4

Abstract

Study of network dynamics is very active area in biological and social sciences. However, the relationship between the network structure and the attractors of the dynamics has not been fully understood yet. In this study, we numerically investigated the role of degenerate self-loops on the attractors and its basin size using the budding yeast cell-cycle network model. In the network, all self-loops negatively suppress the node (self-inhibition loops) and the attractors are only fixed points, i.e. point attractors. It is found that there is a simple division rule of the state space by removing the self-loops when the attractors consist only of point attractors. The point attractor with largest basin size is robust against the change of the self-inhibition loop. Furthermore, some limit cycles of period 2 appear as new attractor when a self-activation loop is added to the original network. It is also shown that even in that case, the point attractor with largest basin size is robust.
自环在出芽酵母细胞周期网络中的作用
网络动力学是生物科学和社会科学中非常活跃的研究领域。然而,网络结构与动力学吸引子之间的关系尚不完全清楚。在本研究中,我们利用出芽酵母细胞周期网络模型,数值研究了简并自环对吸引子及其盆大小的作用。在网络中,所有的自环都负抑制节点(自抑制环),吸引子只有不动点,即点吸引子。当吸引子仅由点吸引子组成时,通过去除自环,发现存在一个简单的状态空间分割规则。池大小最大的点吸引子对自抑制回路的变化具有较强的鲁棒性。此外,在原有网络中加入自激活环时,出现了周期为2的极限环作为新的吸引子。结果还表明,即使在这种情况下,具有最大盆大小的点吸引子也是鲁棒的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
128
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信