Understanding Model Independent Genetic Mutations through Trends in Increase in Entropy

Abstract

Introduction: A mutation, in general, can be defined as a change in the genetic sequence. Mutations can be changes as small as the substitution of a single DNA building block, or nucleotide base, with another nucleotide base. There can be larger mutations which can affect many genes on a chromo-some. In this study we have tried to understand a normal mutation and a failed mutation from the point of view of entropy. We have shown that the entropy range of a normal mutation is less compared to the entropy range of a failed mutation. In this article we have plotted the increase of entropy of both types of mutations mentioned above. Statistical Physics of Partition Function and Entropy: In this section we have used statistical physics to de-fine the partition function of an ensemble. Based on the partition function we have expressed how to calculate physical quantities such as average energy and entropy. Model Independent Mutation Entropy: The entropy of all processes increases. This is true even for biological systems. We have shown the difference between the entropy of a successful mutation and a failed mutation. Conclusion: In conclusion we have shown how the entropy of a successful mutation differs from that of a failed mutation. This opens up future research opportunities where we can apply this to specific biological systems.