Protective effects of extra virgin olive oil against paracetamol-induced liver toxicity in Wistar albino rats

Q3 Agricultural and Biological Sciences
L. Khayyat
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引用次数: 4

Abstract

Background: Paracetamol is an extensively used analgesic and antipyretic drug which Is widely available without a prescription. An overdose of paracetamol can cause liver damage. Extra virgin olive oil (EVOO) Is an organic product which has an antioxidant effect against liver toxicity. The aim of the present study was to Investigate the protective effect of EVOO against the hepatotoxlclty Induced by an overdose of paracetamol In the liver of rats. Material and Methods: Forty adult male rats were used In this study, and were divided Into four groups often rats. Group 1: rats were given distilled water orally and were considered the control group; group 2: rats were given paracetamol orally at a dally dose of 650 mg/kg body weight; group 3: rats were given EVOO orally at a dally dose of 2 mL/kg body weight; group 4: rats were given paracetamol orally (650 mg/kg) and EVOO (2 mL/kg body weight). Blood and liver samples were collected after 15 days of treatment and were prepared for histological, ultrastructural and physiological analyses. Results: Several hlstopathologlcal and ultrastructural changes were observed In group 2, In which rats received paracetamol only. Including cell degeneration, lipid droplets, pyknotlc nuclei, disrupted rER, proliferated sER, changes In mitochondrial structure and congested and expanded blood vessels. Moreover, a significant Increase (p Improvement In histology, ultrastructure of hepatocytes and blood parameters. A significant decrease (p Conclusions: The results obtained In this study Indicated that EVOO has a protective effect against paracetamol overdose-induced hepatotoxlclty.
特级初榨橄榄油对扑热息痛引起的Wistar白化大鼠肝毒性的保护作用
背景:扑热息痛是一种广泛使用的镇痛解热药物,无需处方即可获得。过量服用扑热息痛会导致肝损伤。特级初榨橄榄油(EVOO)是一种有机产品,对肝脏毒性具有抗氧化作用。本研究旨在探讨EVOO对扑热息痛致大鼠肝脏损伤的保护作用。材料与方法:选用成年雄性大鼠40只,分为4组。第一组:大鼠口服蒸馏水,作为对照组;2组:大鼠口服扑热息痛,每日剂量650 mg/kg体重;第三组:大鼠口服EVOO,每日剂量为2 mL/kg体重;4组:大鼠口服扑热息痛(650 mg/kg)和EVOO (2 mL/kg体重)。治疗15 d后采集血液和肝脏标本,进行组织学、超微结构和生理分析。结果:仅给予扑热息痛的第2组大鼠观察到一些组织病理学和超微结构的改变。包括细胞变性、脂滴、核收缩、内质网破坏、sER增生、线粒体结构改变和血管充血扩张。此外,肝细胞的组织学、超微结构和血液参数均有明显改善。结论:本研究结果表明,EVOO对扑热息痛过量引起的肝毒性有保护作用。
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来源期刊
Eurasian Journal of Biosciences
Eurasian Journal of Biosciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍: EurAsian Journal of BioSciences (Abbrev. Eurasia J Biosci or EJOBIOS) is an international, refereed electronic journal. It publishes the results of original research in the field of biological sciences restricted tomorphology, physiology, genetics, taxonomy, ecology and biogeography of both prokaryotic and eucaryotic organisms. The journal encourages submission of manuscripts dealing with plant biology, animal biology, plant physiology, microbiology, hydrobiology, ecology and environmental science, ethnobiology, biodiversity and conservation biology. EurAsian Journal of BioSciences publishes original articles in the following areas: -Agriculture, Fisheries & Food -Anatomy & Morphology -Behavioural Sciences -Biology, Biochemistry and Biotechnology -Biophysics -Biology Education -Cellular Biology and Anatomical Sciences -Ecology, Evolution & Environment -Entomology -Forestry -General Biology -Genetics & Heredity -Life Sciences - Other topics -Microbiology and Immunology -Molecular Biology -Mycology -Palaeontology -Parasitology -Pharmacology & Pharmacy -Physiology and Related Sciences -Plant Sciences -Toxicology -Veterinary Sciences -Virology -Zoology
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