Evaluation of cytotoxic activity of barks of Mimusops elengi

Q3 Agricultural and Biological Sciences

Eurasian Journal of Biosciences Pub Date : 2011-07-01 DOI:10.5053/EJOBIOS.2011.5.0.9

S. Bhujbal, R. Deshmukh, J. Bidkar, V. A. Thatte, S. Awasare, Pratiksha Prahlad Garg

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引用次数: 23

Abstract

Mimusops elengi is a small or large evergreen tree (Sapotaceae) of western peninsula and is found in south India. It has been in use in the indigenous system of medicine since antiquity as a specific cure for the diseases of gum and teeth. The drug has been reported to be bitter, astringent, tonic, febrifuge, and as a cure for dysentery and constipation. The cytotoxic effects of ethanolic extract of barks of M. elengi was investigated on meristimatic cells of root tips of Allium cepa. The experiment was carried out by using different concentrations (2.5, 5, 10 mg/mL) of standard cytotoxic drug cyclophosphamide and ethanolic extract. After 48 h and 96 h root length and mitotic index were calculated. The photomicrographs had shown the chromosomal abnormalities, stickiness, etc. with increasing concentration of ethanolic extract. The results of the presented study revealed that there is a significant decrease in percent mitotic index and root length of A. cepa with respective time and with increasing concentration.

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竹节草树皮细胞毒活性的评价

米苏ops elengi是西部半岛的一种小型或大型常绿乔木(仙人掌科)，发现于印度南部。自古以来，它就被用于本土医学系统中，作为牙龈和牙齿疾病的特殊治疗方法。据报道，这种药是苦的、涩的、滋补的、退热的，可以治疗痢疾和便秘。本文研究了姜皮醇提物对葱根尖分生细胞的细胞毒作用。采用不同浓度(2.5、5、10 mg/mL)的标准细胞毒药物环磷酰胺和乙醇提取物进行实验。48 h和96 h后计算根长和有丝分裂指数。显微照片显示，随着乙醇提取物浓度的增加，染色体出现异常、粘连等现象。结果表明，随着时间和浓度的增加，茜草的有丝分裂指数和根长呈显著下降趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eurasian Journal of Biosciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： EurAsian Journal of BioSciences (Abbrev. Eurasia J Biosci or EJOBIOS) is an international, refereed electronic journal. It publishes the results of original research in the field of biological sciences restricted tomorphology, physiology, genetics, taxonomy, ecology and biogeography of both prokaryotic and eucaryotic organisms. The journal encourages submission of manuscripts dealing with plant biology, animal biology, plant physiology, microbiology, hydrobiology, ecology and environmental science, ethnobiology, biodiversity and conservation biology. EurAsian Journal of BioSciences publishes original articles in the following areas: -Agriculture, Fisheries & Food -Anatomy & Morphology -Behavioural Sciences -Biology, Biochemistry and Biotechnology -Biophysics -Biology Education -Cellular Biology and Anatomical Sciences -Ecology, Evolution & Environment -Entomology -Forestry -General Biology -Genetics & Heredity -Life Sciences - Other topics -Microbiology and Immunology -Molecular Biology -Mycology -Palaeontology -Parasitology -Pharmacology & Pharmacy -Physiology and Related Sciences -Plant Sciences -Toxicology -Veterinary Sciences -Virology -Zoology