Effect Of Admission Hyperglycaemia On Short-Term Outcome In Adult Nigerians With A First Acute Ischaemic Stroke

Abstract

Background There is no information from a prospective study on the relationship between admission hyperglycaemia and stroke outcome in Nigerians. This study was designed to determine the impact of admission hyperglycaemia on short-term stroke outcome (case fatality rate and functional outcome) in adult Nigerians with acute ischaemic stroke. Methods 100 consecutively attending first-ever acute ischemic stroke patients attending our tertiary facility within 72 hours of stroke onset were recruited. Stroke severity on the NIHSS and random blood glucose levels were documented on admission. The outcome measures (case fatality rate and functional status on the NIHSS in survivors) were assessed at 30 days from stroke onset. Results The frequency of admission hyperglycaemia (random blood glucose ≥140mg/dL) was 34%. Baseline stroke severity on the NIHSS was worse in hyperglycaemic patients (median NIHSS 14) compared to normoglycaemic patients (median NIHSS 8). The 30-day case fatality rate was significantly higher in hyperglycaemic compared to normoglycaemic patients (41.2% vs. 21.2%, p Introduction Il n\'y a aucune etude prospective sur la relation entre l\'hyperglycemie et l\'evolution des accidents vasculaires cerebraux chez les nigerians. Objectif Le but de l\'etude est d\'apprecier l\'impact de l\'hyperglycemie a l\'admission et sur l\'evolution a court terme (mortalite et morbidite) sur les malades victimes d\'un accident vasculaire cerebral ischemique (AVCI). Methodes Cent patients, consecutifs, victimes d\'un premier AVCI admis dans notre structure hospitaliere tertiaire dans un intervalle de temps de 72 heures ont ete etudies. La severite de l\'AVCI sur la base de la NIHSS et la glycemie ont ete etudiees. L\'evolution a ete appreciee sur une periode de 30 jours au decours de la survenue de l\'AVCI. Resultats La frequence de l\'hypergycemie (glycemie > ou = 140mg/dl) etait de 34%. La severite de l\'AVC etait superieure chez les patients ayant une hyperglycemie (moyenne NIHSS 14) comparee a ceux qui avaient une normoglycemie (moyenne NIHSS 8). La mortalite a J30 etait significativement plus elevees chez les malades ayant une hyperglycemie par rapport a ceux qui avaient une glycemie normale (41.2% vs. 21.2%, p Keywords : ischemic stroke; Nigerians; hyperglycaemia; functional outcome; mortality African Journal of Neurological Sciences Vol. 26 (2) 2007: pp. 48-57