Synthesis and Biological Activity of Drug Delivery System Based on Chitosan Nanocapsules

Abstract

Chitosan nanocapsules containing naproxen as an active ingredient were synthesized by ionic ge- lation method in presence of polyanion tripolyphosphate as a crosslinker. The morphology and diameter of the prepared chitosan nanoparticles was characterized using scanning electron mi- croscopy and transition electron microscopy. Different factors affecting on the size diameter of chitosan nanoparticles such as stirring time and temperature, pH values as well as chitosan con- centration were studied. Different factors affecting on the immobilization of naproxen into chito- san nanoparticles such as time, temperature and pH values were optimized. Synthesized naprox- en/chitosan nanocapsules were assessed against both Gram positive bacterial strain such as Ba- cillus subtilis and Staphylococcus aureus and Gram negative bacterial strain such as Pseudomonas aeruginosa and Escherichia coli. Also, the antifungal activity of the naproxen/chitosan nanocap- sules against Saccharomyces cerevisiae was demonstrated. Super oxide dismutase like activity of naproxen/chitosan nanocapsules will be determined.