Value of Kolmogorov entropy on the prediction of seizure in epileptic rats

Abstract

Objective To investigate the application of Kolmogorov entropy(KE) in epileptic rats induced by lithium-pilocarpine，and to explore its value in predicting epileptic seizures.Methods Twenty-four Sprague-Dawley(SD) rats were randomly divided into 3 groups：a normal group，a control group and epileptic group.Acute chemical models were made by lithium-pilocarpine.The rats were received continuous electroencephalographic(EEG) monitoring by scalp surface electrode.Changes of KE of EEG signal in the epileptic group were analysis in the whole seizure process and compared with those in the normal group and control group.Results In the whole seizure process of the rats induced by lithium-pilocarpine，KE began to decline during the pre-ictal period and dropped sharply during the ictal period.KE in the pre-ictal and ictal period declined apparently comparing with that in the non-ictal period.KE in the epileptic group had significant differences during the ictal and pre-ictal period compared with that in the normal group and the control group(P<0.05).Conclusions Changes of KE reveal the changes of the complex ictal EEG signals，and may be useful to predict epileptic seizure.