Comparison of serum HBsAg and HBV DNA levels in different degree of hepatic pathological changes in patients with HBV chronic infection

Abstract

Objective　To analyze the relationship among hepatic pathological changes in different degree and HBsAg level as well as HBV DNA in chronic HBV infection patients. Methods　 All 316 chronic HBV infection subjects including 119 with chronic hepatitis B(CHB),99 with liver cirrhosis(LC)and 98 with acute­on­chronic liver failure(ACLF)were enrolled in this study.The differences of serum HBsAg and HBV DNA levels in patients with CHB，LC and ACLF，and in CHB patients with different degree of liver inflammation and fibrosis were compared.HBsAg was assayed with Roche electrochemical luminescence method.HBV DNA was quantified using a real­time polymerase chain reaction(PCR)assay.Liver histological inflammation(G)was graded on a scale from 0 to 4 and histological fibrosis(S) was staged on a scale from 0 to 4.Results　There in CHB，LC and ACLF，were no significant differences between HBsAg and HBV DNA level.Serum HBsAg level in G14 were(288.8±182.1)IU/ml，(264.8±175.6)IU/ml，(279.8±163.6)IU/ml，(317.8±150.0)IU/ml；HBV DNA were(5.0±2.1)log10 IU/ml，(6.1±1.7)log10 IU/ml，(5.6±1.8)log10 IU/ml，(5.8±1.7)log10 IU/ml，respectively.HBsAg level in S01，S2，S3，S4 patients were(234.7±182.5)IU/ml，(261.2±175.6) IU/ml，(305.8±149.2)IU/ml，(320.8±157.4)IU/ml；HBV DNA were(5.5±2.1)log10 IU/ml，(6.2±1.9)log10 IU/ml，(6.0±1.5 log10 IU/ml，(5.3±1.8)log10 IU/ml，respectively.No statistical differences were found among groups.The level of serum albumin in G3，G4 and S3，S4 decreased significantly comparing with other patients.Conclusions　 The degree of hepatic pathological changes did not parallel with serum HBsAg and HBV DNA level in chronic HBV infection patients.