Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
A. Bernardini, Gaia Pellitteri, Giovanni Ermanis, G. Gigli, M. Valente, Francesco Janes
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引用次数: 0

Abstract

Background REM Behavior Disorder (RBD) is considered one of most powerful prodromal condition in different neurodegenerative disorders, mainly alpha-synucleinopathies. A large amount of research recently explored this relationship. Objective and Design The present critically appraised review undertakes this topic, from the perspective of the pathogenetic interplay between clinical manifestations in RBD patients and the misfolding processes that characterize neurodegeneration. In particular, evidence in favor and against the role of RBD as a biomarker of neurodegeneration is discussed. Results and Conclusion The selected papers were functional to structure the review into three main sections: 1) Protein misfolding in neurodegenerative disorders with focus on alpha-synuclein; 2) Clinical features, diagnosis, and pathophysiology of RBD; 3) RBD as a clinical biomarker of protein misfolding. Data herein highlights the current knowledge and the areas of uncertainties in the relationship between RBD and neurodegenerative disorders; we went through preclinical, prodromal and clinical stages of neurodegenerative processes as a useful reference for clinicians involved in brain pathological aging and future research in this field.
快速眼动行为障碍:从蛋白质错误折叠过程到临床病理生理学和转化为神经退行性疾病
背景:在以α -突触核蛋白病为主的神经退行性疾病中,行为障碍(RBD)被认为是最重要的前驱症状之一。最近有大量研究探讨了这种关系。目的和设计本综述从RBD患者的临床表现与神经变性特征的错误折叠过程之间的病理相互作用的角度进行了这一主题的批判性评价。特别是,证据支持和反对RBD作为神经变性的生物标志物的作用进行了讨论。结果与结论所选论文大致可分为三个主要部分:1)以α -突触核蛋白为重点的神经退行性疾病中的蛋白质错误折叠;2) RBD的临床特点、诊断及病理生理;3) RBD作为蛋白质错误折叠的临床生物标志物。这里的数据强调了RBD和神经退行性疾病之间关系的当前知识和不确定领域;我们通过临床前、前驱和临床阶段的神经退行性过程,为临床医生参与脑病理性衰老和该领域的未来研究提供有用的参考。
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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
0.00%
发文量
4
审稿时长
5 weeks
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