Sufeng Ruan, SuFei Yang, Jinrong Li, F. Xiong, D. Qie, You Lu, Zhanghui Tang, Fan Yang
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引用次数: 0
Abstract
Background
Iron deficiency (ID) and ID anemia are widespread in low-income countries, particularly among preterm infants. Hepcidin is a key regulator of iron metabolism, which offers the possibility of new solutions to diagnose ID in premature infants.
Objective
To explore the relationship between iron metabolism and hepcidin in premature infants.
Materials and methods
The study involved 81 preterm infants between 28+1 and 36+6 who underwent iron status indicators and hepcidin testing at 6 months of corrected gestational age. The preterm infants were divided into two groups based on iron status indicators: ID and no ID.
Results
Serum hepcidin was lower for premature infants with ID compared to those without ID (log10hepcidin, 1.18 ± 0.44 vs 1.49 ± 0.37, p = 0.002). A single-variate linear regression model was used to explore the correlation between hepcidin and other indicators of iron metabolism. A strongly positive relationship was observed between hepcidin levels and ferritin levels (p < 0.001) in the correlation analysis.
Conclusions
Hepcidin can be used as an efficient indicator of iron storage and a promising indicator for the early diagnosis of ID in premature infants.