Hepcidin and iron metabolism in preterm infants

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sufeng Ruan, SuFei Yang, Jinrong Li, F. Xiong, D. Qie, You Lu, Zhanghui Tang, Fan Yang
{"title":"Hepcidin and iron metabolism in preterm infants","authors":"Sufeng Ruan, SuFei Yang, Jinrong Li, F. Xiong, D. Qie, You Lu, Zhanghui Tang, Fan Yang","doi":"10.3934/molsci.2023008","DOIUrl":null,"url":null,"abstract":"<abstract><sec> <title>Background</title> <p>Iron deficiency (ID) and ID anemia are widespread in low-income countries, particularly among preterm infants. Hepcidin is a key regulator of iron metabolism, which offers the possibility of new solutions to diagnose ID in premature infants.</p> </sec><sec> <title>Objective</title> <p>To explore the relationship between iron metabolism and hepcidin in premature infants.</p> </sec><sec> <title>Materials and methods</title> <p>The study involved 81 preterm infants between 28<sup>+1</sup> and 36<sup>+6</sup> who underwent iron status indicators and hepcidin testing at 6 months of corrected gestational age. The preterm infants were divided into two groups based on iron status indicators: ID and no ID.</p> </sec><sec> <title>Results</title> <p>Serum hepcidin was lower for premature infants with ID compared to those without ID (log<sub>10</sub>hepcidin, 1.18 ± 0.44 vs 1.49 ± 0.37, <italic>p</italic> = 0.002). A single-variate linear regression model was used to explore the correlation between hepcidin and other indicators of iron metabolism. A strongly positive relationship was observed between hepcidin levels and ferritin levels (<italic>p</italic> < 0.001) in the correlation analysis.</p> </sec><sec> <title>Conclusions</title> <p>Hepcidin can be used as an efficient indicator of iron storage and a promising indicator for the early diagnosis of ID in premature infants.</p> </sec></abstract>","PeriodicalId":44217,"journal":{"name":"AIMS Molecular Science","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIMS Molecular Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3934/molsci.2023008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Iron deficiency (ID) and ID anemia are widespread in low-income countries, particularly among preterm infants. Hepcidin is a key regulator of iron metabolism, which offers the possibility of new solutions to diagnose ID in premature infants.

Objective

To explore the relationship between iron metabolism and hepcidin in premature infants.

Materials and methods

The study involved 81 preterm infants between 28+1 and 36+6 who underwent iron status indicators and hepcidin testing at 6 months of corrected gestational age. The preterm infants were divided into two groups based on iron status indicators: ID and no ID.

Results

Serum hepcidin was lower for premature infants with ID compared to those without ID (log10hepcidin, 1.18 ± 0.44 vs 1.49 ± 0.37, p = 0.002). A single-variate linear regression model was used to explore the correlation between hepcidin and other indicators of iron metabolism. A strongly positive relationship was observed between hepcidin levels and ferritin levels (p < 0.001) in the correlation analysis.

Conclusions

Hepcidin can be used as an efficient indicator of iron storage and a promising indicator for the early diagnosis of ID in premature infants.

早产儿Hepcidin与铁代谢的关系
缺铁和缺铁性贫血在低收入国家普遍存在,尤其是在早产儿中。Hepcidin是铁代谢的关键调节因子,这为早产儿ID的诊断提供了新的解决方案。目的探讨早产儿铁代谢与hepcidin的关系。材料与方法本研究纳入81例28+1 ~ 36+6岁的早产儿,在校正胎龄6个月时接受铁状态指标和hepcidin检测。根据铁状态指标将早产儿分为两组:ID组和无ID组。结果有ID早产儿血清hepcidin低于无ID早产儿(log10hepcidin, 1.18±0.44 vs 1.49±0.37,p = 0.002)。采用单变量线性回归模型探讨hepcidin与其他铁代谢指标的相关性。相关分析显示hepcidin水平与铁蛋白水平呈显著正相关(p < 0.001)。结论shepcidin可作为一种有效的铁储存指标,是早期诊断早产儿ID的一种有前景的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
0.00%
发文量
4
审稿时长
5 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信