Recent developments and future perspectives in aging and macrophage immunometabolism

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
B. Pence
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引用次数: 1

Abstract

Aging is the strongest contributor to the development and severity of many chronic and infectious diseases, primarily through age-related increases in low-grade inflammation (inflammaging) and decreases in immune function (immunosenescence). Metabolic reprogramming in immune cells is a significant contributor to functional and phenotypic changes in these cells, but little is known about the direct effect of aging on immunometabolism. This review highlights several recent advances in this field, focusing on mitochondrial dysfunction, NAD+ metabolism, and therapeutic reprogramming in aged monocytes and macrophages. Perspectives on opportunities for future research in this area are also provided. Targeting immunometabolism is a promising strategy for designing therapeutics for a wide variety of age-related diseases.
衰老与巨噬细胞免疫代谢的研究进展及展望
衰老是许多慢性和传染性疾病的发展和严重程度的最大贡献者,主要是通过年龄相关的低度炎症(炎症)的增加和免疫功能的下降(免疫衰老)。免疫细胞中的代谢重编程是这些细胞功能和表型变化的重要贡献者,但关于衰老对免疫代谢的直接影响知之甚少。本文综述了该领域的最新进展,重点关注线粒体功能障碍、NAD+代谢和老年单核细胞和巨噬细胞的治疗性重编程。最后,对该领域未来的研究前景进行了展望。靶向免疫代谢是设计治疗多种年龄相关疾病的有前途的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
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发文量
4
审稿时长
5 weeks
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