Role of organic anion transporters in xenobiotics induced toxicity

Abstract

It is unavoidable for body to exposure of organic anions including endogenous agents such as hormones,neurotransmitters and cellular metabolites,and xenobiotic agents such as medication,herbicides,pesticides,and plant and animal toxins. Rapid and efficient elimination of toxic substances among them is the body′s best defense. The active transepithelial transport mediated by organic anion transporters is often a rate-limiting step. Therefore,the investigations of organic anion transporters about their classification,tissue distrubution driving force,gene expression and regulatory are of great significance in toxicology.