Effects of Dietary Nucleotides on Immune Mechanisms and Physical State in Children with Chronic Respiratory Problems

Abstract

Heavy industrial pollution and/or passive smoking negatively affect the overall immune health of a population. We used a model of children with chronic respiratory problems and evaluated the effects of short term supplementation of their diet with nucleotides. We measured the level of sIgA, eNO levels and total physical activity. We found positive effects of oral supplementation with commercially available nucleotides. Our data demonstrate strong improvements in physical activity, strong decrease of eNO levels and maintaining of the levels of sIgA. We conclude that supplementation with nucleotides offers an easy way to improve health conditions in children.