CT-guided radioactive 125I seeds implantation as a salvage therapy for adrenal metastases: Evaluation of short-term effect in 11 cases

Abstract

Objective To evaluate the short-term effect and safety of CT-guided radioactive 125I seeds implantation,used as salvage therapy,for adrenal metastases.Methods The clinical data of 11 patients with adrenal metastases,who received radioactive 125I seeds implantation as a salvage therapy,were retrospectively analyzed.The number of lesions was 11 in total,and the longest diameter of the lesions ranged from 2.1 cm to 6.5 cm with a mean of(3.4±1.5) cm.Treatment plan system(TPS) was used to design the optimal distribution and needed number of 125I seeds according to matched peripheral dose(MPD).Under CT guidance,125I seeds were implanted into the adrenal lesions.All patients were followed up for two months,and the overall response rate,quality of life and clinical complications were evaluated.Results The overall response rate,quality of life and clinical complications were assessed at two months after the operation.Of the 11 patients,complete response(CR) was obtained in 3,partial response(PR) in 6 and stable disease(SD)in 2.The remission rate(CR+PR) was 81.8%.The general living quality did not deteriorate when compared with the preoperative condition.The short-term adverse effects were very mild.No severe complications such as hypertensive crisis,massive bleeding,infection,etc.occurred.Conclusion As a salvage therapy for adrenal metastases,CT-guided radioactive 125I seeds implantation is safe,effective and minimally-invasive with fewer and mild complications.Therefore,this technique can be used as an effective local therapy to reduce tumor load.