Therapeutic efficacy of Akarostop for dogs and cats against acariform mite

Abstract

This article is devoted to the study of the effectiveness of the preparation, namely Akarostop, with the active substance amitraz and the excipient dimethyl sulfoxide. The research was conducted with the involvement of pets kept in the private sector and housing (dogs and cats). All research results were controlled by observation of the clinical condition of animals and microscopy of scrapings from the affected areas of the skin and ears. The presence of live mites was determined by lightly warming up the slide. The effectiveness of the drug against sarcoptic mange was established in the treatment of 13 dogs, which were treated once a day with a 3 days interval. Clinical signs of the disease began to resolve in 5–9 days after the first application of the drug, which was manifested by the disappearance of hyperemia, a decrease in exudation, and crusting. The efficiency after two treatments was 40%. On the 21st day before applying the drug, single inactive ticks were found in 5 out of 13 animals in their skin scrapes. The efficacy of the drug against Notoedres in cats was determined, which were treated once a day with a 3 days interval. After 8 days of the treatment in cats' skin scrapings, dead mites and single live ones were found, and on the 13th day crusts dried out, fell away, skin became pale pink and dry. The recovery of animals was observed gradually: on the 13th day it amounted to 33%, on the 17th day – 55%, and residually on the 21st day. Thus, the 100% therapeutic efficacy of the drug Acarostop has been established for the five-time treatment of cats against Notoedres. The efficacy of the preparation for otodectosis of dogs and cats was determined by applying 2–3 drops of the drug into the cleaned ear. Clinical signs of the disease 3–4 days after the first application of the drug began to disappear, which was manifested by the disappearance of hyperemia, a decrease in exudation, falling off crusts, and the absence of itching. On days 5 to 9 from the beginning of treatment all animals recovered, which was confirmed by clinical and laboratory tests. After the tests, the animals continued to be observed and no relapses were found within 4 weeks. In the future, we plan to conduct research on an acaricidal preparation with an improved composition and effect, namely, antipruritic, anti-inflammatory and regenerating effect.