Nonalcoholic fatty liver disease and metabolic syndrome

Abstract

Nonalcoholic fatty liver disease(NAFLD)comprises a disease spectrum which includes variable degrees of simple steatosis nonalcoholic steatohepatitis(NASH) and cirrhosis even liver failure and patocellular carcinoma.NAFLD can be considered the hepatic manifestation of the metabolic syndrome and is an independent predictor of type 2 diabetes(T2DM) and cardiovascular disease(CVD).Insulin resistance is the pathogenetic link between the metabolic syndrome and fat accumulation in the liver.Patients with NAFLD are a high risk population of the both of diseases.It's very important significance to early diagnosis and treatment of NAFLD for prevention T2DM and CVD.