Influence of Polymorphisms on Mycophenolate Mofetil - Induced Diarrhoea in Renal Transplanted Children

Abstract

Purpose: The objective of this study was to investigate the factors involved in mycophenolate mofetil  (MMF) disposition on the risk of diarrhoea in renal transplanted children. Methods: Patients’ characteristics, immunosuppression and polymorphisms of UGT1A8, UGT1A9, UGT2B7, ABCC2, IMPDH1, and IMPDH2 genes were explored. Statistical analyses were performed using logistic regression. Results: Eighty three renal transplanted patients were included and 28/83  (33%) developed diarrhoea requiring MMF discontinuation or switched to the enteric-coated formulation EC-MPS during follow-up. In the multivariate analysis, the risk of diarrhoea was significantly higher in ABCC2 -24CC wild-type patients carrying IMPDH2 IVS7 + 10 T>C variant. Conclusion: IMPDH2  (IVS7+10T>C) and ABCC2  (c.-24C>T) are biomarkers associated with diarrhoea in children treated with MMF.