Progress and Impact of JOPA on Scientific Community

Abstract

Fanconi disorder may be a deformity of proximal tubule driving to malabsorption of different electrolytes and substances that are ordinarily retained by the proximal tubule. It could be a inherited or acquired condition. Anti-viral drugs are now a relatively common cause of Fanconi Syndrome. Nucleoside reverse transcriptase inhibitors (NRTIs) can cause PT toxicity, but it is observed more frequently with the nucleotide reverse transcriptase inhibitors (NtRTIs) adefovir, cidofovir and tenofovir, probably due to the high levels of uptake of these drugs into PT cells via organic anion transporters.