Effect of atorvastatin on the expression of cardiac collagen in atherosclerotic rabbits

中国临床实用医学 Pub Date : 2016-10-25 DOI:10.3760/CMA.J.ISSN.1673-8799.2016.05.012

B. Di, Y. Lu

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Abstract

Objective To establish rabbit atherosclerosis model and to observe the change of cardiac TIMP-4, investigate the chang of cardiac collagen and the effect of atorvastatin on the expression of cardiac collagen in atherosclerotic rabbits. Methods Eighteen male New Zealand white rabbits were randomly divided into three groups: control group, atherosclerosis group, atorvastatin group. To determine the expression of cardiac chymase and TIMP-4, the level of cadiac Ang Ⅱ and cardiac collagen. Result The cardiac chymase expression and cardiacTIMP-4 of AS Group higher than C Group and ATV group(P<0.01) ;The levels of cardiac AngⅡand cardiac collagen in AS group were significantly higher than the C group and ATV group(P<0.01). Conclusions When atherosclerosis occurs, the activation of cardiac renin-angiotensin system mainly in the expression and level of chymase,TIMP-4,Ang Ⅱ and cardiac collagen were markedly elevated, which cause collagen hyperplasia and fibrosis of myocardium. Atorvastatin could restrain cardiac renin-angiotensin system, and prevent the hyperplasia of cardiac collagen and the fibrosis of cardiac extracellular matrix. Key words: atherosclerosis; cardiac collagen; chymase; TIMP-4; AngⅡ; atorvastatin

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阿托伐他汀对动脉粥样硬化兔心脏胶原蛋白表达的影响

目的建立家兔动脉粥样硬化模型，观察心脏TIMP-4的变化，探讨心脏胶原蛋白的变化及阿托伐他汀对动脉粥样硬化家兔心脏胶原蛋白表达的影响。方法18只雄性新西兰大白兔随机分为3组:对照组、动脉粥样硬化组、阿托伐他汀组。测定心肌酶和TIMP-4的表达、心肌AngⅡ和心肌胶原蛋白的水平。结果AS组大鼠心肌切酶表达、cardiacTIMP-4均高于C组和ATV组(P<0.01); AS组大鼠心肌AngⅡ、胶原蛋白水平均显著高于C组和ATV组(P<0.01)。结论动脉粥样硬化发生时，心肌肾素-血管紧张素系统的激活主要表现为酶切酶、TIMP-4、AngⅡ及心肌胶原蛋白的表达和水平明显升高，导致心肌胶原增生和纤维化。阿托伐他汀能抑制心肌肾素-血管紧张素系统，防止心肌胶原增生和心肌细胞外基质纤维化。关键词:动脉粥样硬化;心脏胶原蛋白;chymase;TIMP-4;AngⅡ;阿托伐他汀

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中国临床实用医学

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