Pregnancy Complication in Patients with Paroxysmal Nocturnal Haemoglobinuria

Abstract

Paroxysmal nocturnal haemoglobinuria (PNH) may be a rare haematological disease with an incidence of 1:100 000 to 1:500 000per year. It’s presented with triad of anaemia, bone marrow (BM) failure, and thrombosis. There are often noted variations within the PNH symptoms in several individuals. Sometimes, PNH are often quite asymptomatic and thus it's important to rule out the presence of this disorder in uncertain cases of hemolytic, thrombosis or cytopenia. PNH primarily affects adults including women of reproductive age. Although the disease includes chronic symptoms, spontaneous remissions are known to happen in certain cases also.