Comparative analysis of risk factors for large-artery atherosclerotic cerebral infarction in different age groups

中国医师进修杂志 Pub Date : 2012-10-05 DOI:10.3760/CMA.J.ISSN.1673-4904.2012.28.007

Xin Liu, Dan-yu Gao, Jin Hu, San-dong Dai

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Abstract

Objective To explore different risk factors in different age groups patients with large-artery atherosclerotic cerebral infarction,in order to reduce the rates of cerebral infarction and relapse by taking different means of prevention.Methods One hundred and ninety-two patients with large-artery atherosclerotic cerebral infarction were divided into three groups by age:youth group (46 cases),middle age group (57 cases) and elderly group (89 cases).The study variables included sex,previous medical history (hypertension and diabetes),long-term smoking,long-term alcohol intake and laboratory parameters (triglyceride,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,homocysteine).Results The rates of high triglyceride and long-term smokingin youth group were significantly higher than those in elderly group [ 60.9％ (28/46) vs.22.5％ (20/89),65.2％ (30/46) vs.29.2％ (26/89),P ＜ 0.05 ].The rates of male,long-term smoking and long-term alcohol intake in middle age group were significantly higher than those in elderly group [ 80.7％ (46/57) vs.59.6％ (53/89),57.9％ (33/57) vs.29.2％ (26/89),47.4％ (27/57) vs.15.7％ (14/89),P ＜ 0.05 ].The rates of hypertension,diabetes and long-term alcohol intake in middle age group were significantly higher than those in youth group [ 84.2％ (48/57) vs.60.9％ (28/46),54.4％ (31/57 ) vs.26.1％ ( 12/46 ),47.4％ (27/57) vs.23.9％ ( 11/46 ),P ＜ 0.05 ].The rate of high triglyceride in youth group was significantly higher than that in middle age group [60.9％(28/46) vs.29.8％(17/57),P ＜ 0.05 ].The rate of hypertension in elderly group was significantly higher than that in youth group [ 83.1％(74/89) vs.60.9％ (28/46),P ＜0.05].There was no significant difference in low-density lipoprotein cholesterol,homocysteine and high-density lipoprotein cholesterol in the three groups (P ＞0.05).Conclusions Key point is different for the prevention of large-artery atherosclerosis cerebral infarction of different age paragraph.The youth patient emphasizes the change of lifestyle.Middle age patient has more emphasis on blood pressure,blood glucose control of the risk factors based on the lifestyle change.The key of elderly patient is the control of blood pressure. Key words: Brain infarction; Atherosclerosis; Risk factors

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不同年龄组大动脉粥样硬化性脑梗死危险因素的比较分析

目的探讨不同年龄组大动脉粥样硬化性脑梗死患者的不同危险因素，通过采取不同的预防措施，降低脑梗死的发生率和复发率。方法192例大动脉粥样硬化性脑梗死患者按年龄分为青年组(46例)、中年组(57例)和老年组(89例)。研究变量包括性别、既往病史(高血压和糖尿病)、长期吸烟、长期饮酒和实验室参数(甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、同型半胱氨酸)。结果青年组高甘油三酯和长期吸烟的比例明显高于老年组[60.9%(28/46)比22.5%(20/89)，65.2%(30/46)比29.2% (26/89)，P < 0.05]。男性、长期吸烟、长期饮酒比例中年组明显高于老年组[80.7% (46/57)vs.59.6%(53/89)、57.9% (33/57)vs.29.2%(26/89)、47.4% (27/57)vs.15.7% (14/89)，P < 0.05]。中年组高血压、糖尿病、长期饮酒发生率均显著高于青年组[84.2% (48/57)vs.60.9% (28/46)，54.4% (31/57) vs.26.1% (12/46)，47.4% (27/57) vs.23.9% (11/46)，P < 0.05]。青壮年组高甘油三酯率显著高于中年组[60.9%(28/46)比29.8%(17/57)，P < 0.05]。老年组高血压患病率明显高于青年组[83.1%(74/89)比60.9% (28/46)，P <0.05]。三组患者低密度脂蛋白胆固醇、同型半胱氨酸和高密度脂蛋白胆固醇比较，差异均无统计学意义(P < 0.05)。结论不同年龄阶段预防大动脉粥样硬化性脑梗死的要点不同。青年病人强调生活方式的改变。中年患者更强调在改变生活方式的基础上控制血压、血糖等危险因素。老年病人的关键是控制血压。关键词:脑梗死;动脉粥样硬化;风险因素

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来源期刊

中国医师进修杂志

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期刊介绍： Chinese Journal of Postgraduates of Medicine (founded in 1978, monthly) is one of the series of journals of the Chinese Medical Association (CMA) under the supervision of the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association (CMA) and Dalian Institute of Theoretical Medicine (DITM). It is a core journal of Chinese science and technology, a statistical source journal of Chinese scientific and technical papers, and a statistical source journal of China Academic Journal Impact Factor Annual Report. The journal adheres to the purpose of using continuing medical education and post training, highlights new theories, new knowledge, new methods and new technologies, and focuses on the combination of theory and practice, and the combination of popularisation and improvement. Main columns: Special tutorials, expert forums, clinical treatises, clinical experience, reviews and lectures, continuing medical education, teaching and research, advanced training forum, drugs and clinics, overview of progress, introduction of new technologies, imaging and clinics, lessons learnt, discussions and evaluations, case reports, discussions of clinical cases, conference proceedings, and domestic and international academic developments. The main target readers are clinical medical personnel in internal medicine, surgery, gynaecology, paediatrics and ophthalmology.