Correlation between serum uric acid level and severity of coromry artery

中国医师进修杂志 Pub Date : 2011-10-25 DOI:10.3760/CMA.J.ISSN.1673-4904.2011.30.009

Wei Zhao, Wenbing Jiang, Dong-chu Zhang, Lu Yu, Y. Wang, Jian-hua Zhang

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Abstract

Objective To investigate the correlation between serum uric acid level and severity of coronary artery disease.Methods The concentrations of serum uric acid in 112 patients whom had received coronary arteriongraphy(CAG) was measured,among of them,acute coronary artery syndrome (ACS) with 58 cases( ACS group ),stable angina cordis with 25 cases( stable angina cordis group),non-coronary disease with 29 cases(control group).The severity of coronary artery lesion was evaluated by the number of stenosis vessel and Gensini score.They were divided into control group (29 cases),single vessel lesion group (24 cases),double vessel lesion group(26 cases),triple vessel lesion group(33 cases ) according to the number of stenosis vessel and 0-1 score group(29 cases),2-20 scores group(28 cases),21-40 scores group(30 cases),＞40 scores group (25 cases) according to the Gensini score.Results The concentrations of serum uric acid in ACS group were higher than those in control group and stable angina cordis group[ (369.61 ± 91.97 ) μ mol/Lvs. (298.33 ±92.46),(330.43 ±87.42)μmol/L] (P ＜0.05).The concentrations of serum uric acid in control group were lower than those in single vessel lesion group,double vessel lesion group and triple vessel lesion group [(298.33 ±92.46)μmol/L vs. (331.77 ±86.33),(368.24 ±95.21),(396.82 ±94.45) μ mol/L] (P ＜ 0.05).The concentrations of serum uric acid in single vessel lesion group were significantly lower than those in double vessel lesion group and triple vessel lesion group (P ＜ 0.05 ).The concentrations of serum uric acid in 0-1 score group [ (298.33 ± 92.46) μ mol/L] and 2-20 scores group [ (320.77 ± 86.33 ) μ mol/L ] were respectively lower than those in 21-40 scores group [ (366.61 ± 91.97 ) μ mol/L ] and ＞ 40 scores group [ (402.82 ± 91.97 ) μ mol/L] (P ＜ 0.05 ).The concentrations of serum uric acid in ＞ 40 scores group was higher than that in 21-40 scores group (P ＜ 0.05 ).Serum uric acid concentrations was positively correlated with the log of Gensini score (r =0.348,P ＜ 0.05 ).Conclusion The increase in serum uric acid might reflect increase in severity of coronary artery stenosis. Key words: Coronary disease; Uric acid; Gensini coronary score

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血尿酸水平与冠状动脉严重程度的相关性研究

目的探讨血清尿酸水平与冠心病严重程度的相关性。方法对112例行冠状动脉造影(CAG)的患者进行血清尿酸测定，其中急性冠状动脉综合征(ACS) 58例(ACS组)，稳定型心绞痛25例(稳定型心绞痛组)，非冠状动脉病变29例(对照组)。采用狭窄血管数和Gensini评分评价冠状动脉病变的严重程度。按狭窄血管数分为对照组(29例)、单血管病变组(24例)、双血管病变组(26例)、三血管病变组(33例)，按Gensini评分分为0-1分组(29例)、2-20分组(28例)、21-40分组(30例)、bbb40分组(25例)。结果ACS组血清尿酸浓度明显高于对照组和稳定型心绞痛组[(369.61±91.97)μ mol/Lvs]。(298.33±92.46)μmol/L，(330.43±87.42)μmol/L，差异有统计学意义(P <0.05)。对照组血清尿酸浓度低于单血管病变组、双血管病变组和三血管病变组[(298.33±92.46)μmol/L比(331.77±86.33)、(368.24±95.21)、(396.82±94.45)μmol/L] (P < 0.05)。单血管病变组血清尿酸浓度显著低于双血管病变组和三血管病变组(P < 0.05)。0-1分组血清尿酸浓度[(298.33±92.46)μ mol/L]、2-20分组血清尿酸浓度[(320.77±86.33)μ mol/L]分别低于21-40分组[(366.61±91.97)μ mol/L]和bbb40分组[(402.82±91.97)μ mol/L] (P < 0.05)。bbb40评分组血清尿酸浓度高于21-40评分组(P < 0.05)。血清尿酸浓度与Gensini评分对数呈正相关(r =0.348,P < 0.05)。结论血尿酸升高可能反映了冠状动脉狭窄程度的增加。关键词:冠心病;尿酸;Gensini冠状动脉评分

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中国医师进修杂志

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期刊介绍： Chinese Journal of Postgraduates of Medicine (founded in 1978, monthly) is one of the series of journals of the Chinese Medical Association (CMA) under the supervision of the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association (CMA) and Dalian Institute of Theoretical Medicine (DITM). It is a core journal of Chinese science and technology, a statistical source journal of Chinese scientific and technical papers, and a statistical source journal of China Academic Journal Impact Factor Annual Report. The journal adheres to the purpose of using continuing medical education and post training, highlights new theories, new knowledge, new methods and new technologies, and focuses on the combination of theory and practice, and the combination of popularisation and improvement. Main columns: Special tutorials, expert forums, clinical treatises, clinical experience, reviews and lectures, continuing medical education, teaching and research, advanced training forum, drugs and clinics, overview of progress, introduction of new technologies, imaging and clinics, lessons learnt, discussions and evaluations, case reports, discussions of clinical cases, conference proceedings, and domestic and international academic developments. The main target readers are clinical medical personnel in internal medicine, surgery, gynaecology, paediatrics and ophthalmology.