Cholesterol: An evergreen molecule in biology

IF 0.3 Q4 SPECTROSCOPY

Biomedical Spectroscopy and Imaging Pub Date : 2016-01-01 DOI:10.3233/BSI-160159

G. Kumar, A. Chattopadhyay

引用次数: 15

Abstract

Cholesterol, an essential component of higher eukaryotic membranes, was discovered more than two centuries ago. The development and progress of cholesterol research in the last 200 years has been truly fascinating, with elements of surprise, serendipity and intrigue. In this review, we trace this journey the way we see it, and follow it up with the role of membrane cholesterol in crucial areas of contemporary research (transbilayer domains, regulation of GPCR function and role in the entry of intracellular pathogens into host cells), with considerable footprint from our work. We believe that cholesterol will continue to surprise and fascinate future researchers, thereby justifying its evergreen nature.

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胆固醇:生物学中的常绿分子

胆固醇是高级真核生物膜的重要组成部分，早在两个多世纪前就被发现了。在过去的200年里，胆固醇研究的发展和进步确实令人着迷，其中充满了惊喜、意外和阴谋。在这篇综述中，我们追溯了我们所看到的这段旅程，并在当代研究的关键领域(跨双层结构域，GPCR功能的调节和细胞内病原体进入宿主细胞中的作用)中追踪了膜胆固醇的作用，并从我们的工作中获得了相当大的足迹。我们相信，胆固醇将继续让未来的研究人员感到惊讶和着迷，从而证明它的常青性是正确的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedical Spectroscopy and Imaging SPECTROSCOPY-

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期刊介绍： Biomedical Spectroscopy and Imaging (BSI) is a multidisciplinary journal devoted to the timely publication of basic and applied research that uses spectroscopic and imaging techniques in different areas of life science including biology, biochemistry, biotechnology, bionanotechnology, environmental science, food science, pharmaceutical science, physiology and medicine. Scientists are encouraged to submit their work for publication in the form of original articles, brief communications, rapid communications, reviews and mini-reviews. Techniques covered include, but are not limited, to the following: • Vibrational Spectroscopy (Infrared, Raman, Teraherz) • Circular Dichroism Spectroscopy • Magnetic Resonance Spectroscopy (NMR, ESR) • UV-vis Spectroscopy • Mössbauer Spectroscopy • X-ray Spectroscopy (Absorption, Emission, Photoelectron, Fluorescence) • Neutron Spectroscopy • Mass Spectroscopy • Fluorescence Spectroscopy • X-ray and Neutron Scattering • Differential Scanning Calorimetry • Atomic Force Microscopy • Surface Plasmon Resonance • Magnetic Resonance Imaging • X-ray Imaging • Electron Imaging • Neutron Imaging • Raman Imaging • Infrared Imaging • Terahertz Imaging • Fluorescence Imaging • Near-infrared spectroscopy.