Nicotinamide Phosphoribosyl Transferase and Cancer: A Molecular Nutrition Link

L. Q. Zhang, D. Heruth, Mark Lee Jr., Ding-You Li, D. Maulik, S. Ye
{"title":"Nicotinamide Phosphoribosyl Transferase and Cancer: A Molecular Nutrition Link","authors":"L. Q. Zhang, D. Heruth, Mark Lee Jr., Ding-You Li, D. Maulik, S. Ye","doi":"10.34175/jno201601005","DOIUrl":null,"url":null,"abstract":"Nicotinamide phosphoribosyl transferase (NAMPT, EC 2.4.2.12), a pleiotropic protein, is a key enzyme for cellular NAD synthesis and may function as a growth factor or cytokine. Dysregulation of NAMPT gene expression has been implicated in several human diseases. In recent years, an increasing attention has been drawn to NAMPT’s role in the pathogenesis of cancer and its value as a therapeutic target in cancer therapy. A molecular nutrition link between NAMPT and cancer looms large among the scientific findings. This review article will be centered on this theme. We will summarize the genomic discoveries of NAMPT in cancer and the current understanding of molecular mechanisms underlying NAMPT in the pathogenesis of cancer, especially on a molecular nutrition link. We will also synopsize several small molecule inhibitors of NAMPT and their potential therapeutic utilities in cancer and usher in some terra incognita of future researches on NAMPT in cancer.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutritional Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.34175/jno201601005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Nicotinamide phosphoribosyl transferase (NAMPT, EC 2.4.2.12), a pleiotropic protein, is a key enzyme for cellular NAD synthesis and may function as a growth factor or cytokine. Dysregulation of NAMPT gene expression has been implicated in several human diseases. In recent years, an increasing attention has been drawn to NAMPT’s role in the pathogenesis of cancer and its value as a therapeutic target in cancer therapy. A molecular nutrition link between NAMPT and cancer looms large among the scientific findings. This review article will be centered on this theme. We will summarize the genomic discoveries of NAMPT in cancer and the current understanding of molecular mechanisms underlying NAMPT in the pathogenesis of cancer, especially on a molecular nutrition link. We will also synopsize several small molecule inhibitors of NAMPT and their potential therapeutic utilities in cancer and usher in some terra incognita of future researches on NAMPT in cancer.
烟酰胺磷酸核糖基转移酶与癌症:一个分子营养联系
烟酰胺磷酸核糖转移酶(Nicotinamide phosphororibosyl transferase, NAMPT, EC 2.4.2.12)是一种多效蛋白,是细胞合成NAD的关键酶,可能具有生长因子或细胞因子的功能。NAMPT基因表达失调与几种人类疾病有关。近年来,NAMPT在肿瘤发病机制中的作用及其作为肿瘤治疗靶点的价值越来越受到人们的关注。在科学发现中,NAMPT和癌症之间的分子营养联系显得尤为突出。这篇综述文章将围绕这个主题展开。我们将总结NAMPT在癌症中的基因组发现以及目前对NAMPT在癌症发病中的分子机制的理解,特别是在分子营养方面的联系。我们还将简要介绍NAMPT的几种小分子抑制剂及其在癌症中的潜在治疗作用,并对NAMPT在癌症研究中的一些未知领域进行展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
154
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信