Comparison of Clinicopathological Characteristics of BRCA1 and BRCA2 Carriers with Breast Cancer: The Role of Ki-67 Index

Abstract

91 One in 8 women in the community are predisposed to develop breast cancer, and this risk significantly escalates in women with a family history of breast carcinoma.1,2 Approximately, 10% of breast cancers are hereditary, and mutation in the breast cancer (BRCA) gene is one of the best-known mutations associated with breast cancer.2-5 The factors that increase the chances of a BRCA mutation in breast cancer include young age (<40 years), triple-negative tumors, male gender, family history, ovarian cancer, and bilateral breast cancer.6 Currently, BRCA mutations are evaluated in 2 subgroups, BRCA1 and BRCA2, and patients with BRCA mutations can develop secondary malignancies.