Uday Bir Shahi, Ashish Acharya, S. Timalsina, A. Gautam, K. Swain, Sandesh Panthi
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引用次数: 0
Abstract
Background of the study: Depression is a prevalent mental disorder characterized by various symptoms, including low mood, lack of pleasure, changes in appetite and sleep, and difficulty concentrating. Antidepressants are commonly used to manage depression as well as other related disorders, such as anxiety and somatoform disorders. This study aimed to investigate the adverse drug effects experienced by adult patients who were using antidepressants at Chitwan Medical College Teaching Hospital in Nepal. Methods: This study was a retro-prospective, observational study consisting of 117 adult patients under antidepressant medication. The adverse drug profile for the patients was collected using an antidepressant side effect checklist developed by the NHS foundation trust. Statistical analysis was performed using SPSS version 20. Result: The study group consisted of adult patients using antidepressants at Chitwan Medical College Teaching Hospital, Chitwan, Nepal. The mean age of the group was 40.9 ± 12.8, with 63.2% females and 36.7% males. The most common conditions for which antidepressants were prescribed were depression (49.5%), anxiety disorder (31.6%), and somatoform disorder (13.6%). Amitriptyline was the most commonly used medication in monotherapy (64.1%), followed by escitalopram and sertraline. Dry mouth, weight gain, drowsiness, blurred vision, problems with sexual function, and an increase in appetite were the most commonly reported adverse effects. The incidence of certain adverse effects was higher in the multiple therapy group than in the monotherapy group (p < 0.05). Conclusion: The incidence of adverse drug effects is high in patients taking antidepressants, especially those receiving multiple medications. Educating patients about common side effects and prescribing monotherapy whenever possible are crucial in reducing the incidence.
研究背景:抑郁症是一种普遍存在的精神障碍,其特征是各种症状,包括情绪低落、缺乏快乐、食欲和睡眠变化以及注意力难以集中。抗抑郁药通常用于治疗抑郁症以及其他相关疾病,如焦虑和躯体形式障碍。本研究旨在调查尼泊尔奇旺医学院教学医院成年患者使用抗抑郁药的不良反应。方法:本研究是一项回顾性、前瞻性、观察性研究,包括117例服用抗抑郁药物的成年患者。使用NHS基金会信托开发的抗抑郁药副作用清单收集患者的不良药物概况。采用SPSS version 20进行统计分析。结果:研究对象为尼泊尔奇旺医学院附属医院使用抗抑郁药物的成年患者。患者平均年龄40.9±12.8岁,女性占63.2%,男性占36.7%。开具抗抑郁药的最常见病症是抑郁症(49.5%)、焦虑症(31.6%)和躯体形式障碍(13.6%)。阿米替林是单药治疗中最常用的药物(64.1%),其次是艾司西酞普兰和舍曲林。口干、体重增加、嗜睡、视力模糊、性功能问题和食欲增加是最常见的不良反应。综合治疗组某些不良反应发生率高于单药治疗组(p < 0.05)。结论:抗抑郁药物的不良反应发生率较高,尤其是合并多种药物的患者。教育患者了解常见的副作用,并尽可能开具单药治疗处方,对于降低发病率至关重要。