Long-Expected New Start.

H. Noguchi
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引用次数: 0

Abstract

On behalf of the Japan Society for Organ Preservation and Medical Biology (JSOPMB), I express my sincere appreciation to Professor Paul R. Sanberg (Department of Neurosurgery, College of Medicine, University of South Florida, FL, USA), Executive Editor of Cell Medicine, for providing us such an excellent opportunity to publish the data that were presented at the annual meeting of JSOPMB. I also thank Dr. David Eve, Associate Editor of Cell Medicine, for editing our papers in detail. I am very sure that the relationship between Cell Medicine and JSOPMB has enhanced the motivation of JSOPMB members as well as board members and will continue to do so in the future, while also encouraging young Japanese researchers to newly join this organization. Cell-based therapy is one of the most important medical fields in JSOPMB because this form of therapy can be useful for a wide range of diseases. Addressing the current problem of severe human donor organ shortage for cell therapies is a big challenge. Research on adult and embryonic stem cells and artificial cell development, in addition to the recent and rapidly evolving invention of induced pluripotent stem (iPS) cells, encourages us to address the problems confronting cell transplantation. Therefore, JSOPMB has now importantly focused on regenerative medicine in collaboration with cell biologists. One of the extremely important missions of the annual meeting of JSOPMB is to exchange new research outcomes and create new therapeutic concepts. JSOPMB always encourages and motivates young investigators. JSOPMB was started in 1974 for the study of organ preservation and developed widely in the 1990s with the participation of researchers in various fields of medicine, pharmacology, engineering, veterinary medicine, and basic science. Currently, JSOPMB has more than 400 members and is run under the direction of Dr. Takehide Asano, the current President of JSOPMB. Excellent presentations conducted at the 38th annual meeting of JSOPMB held on November 25–26, 2011, in Miyagi, Japan, under the supervision of Dr. Takashi Kondo (Professor, Department of Thoracic Surgery, Tohoku University, Miyagi, Japan) were selected and given an opportunity to be published in this special issue of Cell Medicine. Nine of these presentations are herein published in this special JSOPMB issue. Teratani and Kobayashi reviewed results from various groups using their transgenic rats for direct visualization of their tissues at the bench level and in cell transplantation research. This included studies on renal and liver injury, parkinsonian models, and nerve injury and islet isolation. Diabetes continued to be a major focus with two review papers evaluating different aspects of islet transplantation. Kataoka and Noguchi reviewed the relationship between ER stress and the pathogenesis of type 1 and type 2 diabetes and the association between islet transplantation and ER stress. Maruyama et al. reviewed autologous islet transplantation. Stem cell research was a major topic of interest. There were two papers regarding pancreatic stem cells. One by Noguchi et al. explored the culture conditions for mouse pancreatic stem cells, while the other by Kuise et al. the isolation efficiency of mouse pancreatic stem cells. In addition, Kasahara et al. reported that protein fractions secreted by mesenchymal stem cells (MSCs) were capable of activating preserved islets. There were three papers regarding hepatocytes. Dosen et al. reported that hepatic ischemic reperfusion injury could be reduced using saline exposed to electron discharge in a rat model. Miyamoto et al. synthesized positively charged magnetic nanoparticles and observed these nanoparticles inside three-dimensional models of HepG2 spheroids, which mimic tissues. Finally, Hsu et al. showed that citrate phosphate dextrose-supplemented Euro-Collins solution improved the recovery of hepatocytes isolated from warm ischemic rat liver. The theme of this JSOPMB issue is “Long-Expected New Start.” The board members and I are looking forward to seeing further progress in JSOPMB in conjunction with Cell Medicine.
期待已久的新开始。
我谨代表日本器官保存与医学生物学学会(JSOPMB)向《细胞医学》杂志的执行编辑Paul R. Sanberg教授(美国佛罗里达州南佛罗里达大学医学院神经外科)表示衷心的感谢,感谢他为我们提供了这样一个绝佳的机会来发表在JSOPMB年会上提交的数据。我还要感谢《细胞医学》的副主编David Eve博士对我们论文的详细编辑。我非常确信,细胞医学与JSOPMB之间的关系增强了JSOPMB成员和董事会成员的动力,并将在未来继续这样做,同时也鼓励年轻的日本研究人员加入这个组织。细胞治疗是JSOPMB中最重要的医学领域之一,因为这种形式的治疗可用于广泛的疾病。解决当前严重的人类供体器官短缺问题是一个巨大的挑战。对成体和胚胎干细胞和人工细胞发育的研究,以及最近和快速发展的诱导多能干细胞(iPS)的发明,鼓励我们解决细胞移植面临的问题。因此,JSOPMB现在与细胞生物学家合作,重点关注再生医学。JSOPMB年会的一个极其重要的任务是交流新的研究成果和创造新的治疗理念。JSOPMB一直鼓励和激励年轻的调查人员。JSOPMB成立于1974年,目的是研究器官保存,在20世纪90年代得到了医学、药理学、工程、兽医学和基础科学等各个领域的研究人员的广泛发展。目前,JSOPMB有400多名成员,并在JSOPMB现任主席浅野武雄博士的指导下运作。2011年11月25日至26日,在日本宫城举行的JSOPMB第38届年会上,在Takashi Kondo博士(日本宫城东北大学胸外科教授)的监督下,优秀的报告被选中并有机会发表在这期《细胞医学》特刊上。其中的9个演讲将在本期JSOPMB特刊中发表。Teratani和Kobayashi回顾了不同小组使用转基因大鼠在实验台上和细胞移植研究中直接可视化其组织的结果。这包括肾脏和肝脏损伤、帕金森模型、神经损伤和胰岛分离的研究。糖尿病仍然是一个主要的焦点,两篇综述论文评估了胰岛移植的不同方面。Kataoka和Noguchi综述了内质网应激与1型和2型糖尿病发病机制的关系,以及胰岛移植与内质网应激的关系。Maruyama等人回顾了自体胰岛移植。干细胞研究是一个重要的话题。有两篇关于胰腺干细胞的论文。Noguchi等人研究了小鼠胰腺干细胞的培养条件,Kuise等人研究了小鼠胰腺干细胞的分离效率。此外,Kasahara等人报道了间充质干细胞(MSCs)分泌的蛋白质组分能够激活保存的胰岛。有三篇关于肝细胞的论文。Dosen等人报道了在大鼠模型中使用暴露于电子放电的生理盐水可以减轻肝缺血再灌注损伤。Miyamoto等人合成了带正电荷的磁性纳米颗粒,并在模拟组织的HepG2球体三维模型中观察这些纳米颗粒。最后,Hsu等人的研究表明,柠檬酸磷酸葡萄糖补充Euro-Collins溶液可以促进热缺血大鼠肝脏分离的肝细胞的恢复。本期JSOPMB的主题是“期待已久的新起点”。董事会成员和我都期待着JSOPMB与细胞医学联合取得进一步进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell medicine
Cell medicine MEDICINE, RESEARCH & EXPERIMENTAL-
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