The Prognostic Value of Platelet–lymphocyte Ratio (PLR) in Patients with Non ST Segment Elevation Myocardial Infarction (NSTEMI)

Abstract

Background: Inflammation characterizes atherothrombosis and the presence of inflammation at the site of the atherosclerotic lesion has a role in plaque formation and acute rupture. Previous studies demonstrated that elevated peripheral blood platelet count and a low peripheral blood lymphocyte count are associated with major adverse cardiovascular outcomes. Therefor we supposed that; platelet-lymphocyte ratio (PLR) may have a prognostic value in patients with NSTSEMI. Patents and Methods: 90 patients with NSTEMI were included in our study. Then Complete history was taken, General and local examination were done, Blood sample was taken for laboratory tests with especial interest to PLR, ECG, and bedside screening ECHO were done on admission. Lastly, Coronary angiography; SYNTAX (SX) score, TIMI flow and myocardial blush grade (MBG) were estimated. Results: After classified our study population (90 patients) into three groups: Group 1 (N = 55): EF ˃ 50%. Group 2 (N = 16): EF 40-50%. Group 3 (N = 19): EF ˂ 40%. There was highly statistically significant difference between three groups regarding platelets, lymphocytes and PLR (P<0.001). PLR >149.05 had statistically highly significant positive correlation with SX score and troponin (p<0.001), on the other hand PLR had statistically highly significant negative correlation with EF and MBG (p<0.001) and had statistically significant negative correlation with TIMI flow (p<0.05). Conclusion: PLR >149.05 was associated with LV systolic dysfunction with sensitivity and specificity 100% and 84.5%, respectively.