A Real World Cost Comparison between Chinese Patients with Coronary Heart Disease or Angina Pectoris using Salvianolate and without using Salvianolate: A Retrospective Database Analysis

J. Xuan, Yingrui Xu, HongYing Liu, Yue Gao, Linguo Li
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Abstract

Objective: To assess and compare 1-year cardiovascular events occurrence frequency and treatment cost among Chinese coronary heart disease (CHD) or angina pectoris patients who used salvianolate injection or non-user. Method: Data were obtained from electronic medical record (EMR) database between 2012.01.01~2017.12.31 covering medical encounter records from two tier-3 general hospitals from Shanghai and Guangzhou in China. Patients were followed 12 months after drug initiation. T-test, Chi-square test, negative binomial regression and generalized linear model adjusting for demographics, and baseline characteristics including cardiovascular event (myocardial infarction, angina, transient ischemic attack, stroke, etcs) rate, inpatient length of stay, and healthcare resource consumption were used to test the difference between two groups. Result: A total of 439 and 1848 patients were identified for salvianolate injection and control group, with mean (SD) age 75.42 (12.09) and 69.15 (12.79) (p<0.01) and male 43.28% and 52.38% (p<0.01), respectively. During baseline, the mean frequency of cardiovascular events were 2.05 and 5.82 times for treatment and control group respectively (p<0.01); the treatment cost for cardiovascular event were 4720.04 Chinese Yuan (CNY) and 3700.23 CNY for control group respectively (p=0.11). During the follow-up period, the average number of cardiovascular events were 0.26 and 5.87 times for treatment and control group respectively (p<0.01). Compared with non-user, mean per-year cost for salvianolate injection user was 29.58% lower (4069.21 vs. 5778.17 Chinese Yuan (CNY). Conclusion: Among Chinese coronary heart disease and angina pectoris patients, those who used salvianolate injection had lower per-year cardiovascular event rate and spent less on cardiovascular events treatment.
中国冠心病或心绞痛患者使用丹参酚酸酯和不使用丹参酚酸酯的成本比较:回顾性数据库分析
目的:评价和比较中国冠心病(CHD)或心绞痛患者使用丹参酚酸注射液和未使用丹参酚酸注射液的1年心血管事件发生频率和治疗费用。方法:数据来源于中国上海和广州两家三级综合医院的电子病历数据库(EMR),时间为2012.01.01~2017.12.31。患者在用药后12个月随访。采用t检验、卡方检验、负二项回归和人口统计学校正的广义线性模型,以及心血管事件(心肌梗死、心绞痛、短暂性脑缺血发作、卒中等)发生率、住院时间、医疗资源消耗等基线特征检验两组间的差异。结果:丹参酚酸酯注射液组和对照组共检出439例和1848例患者,平均(SD)年龄分别为75.42(12.09)和69.15 (12.79)(p<0.01),男性分别为43.28%和52.38% (p<0.01)。基线时,治疗组和对照组心血管事件平均频次分别为2.05次和5.82次(p<0.01);对照组心血管事件治疗费用分别为4720.04元和3700.23元(p=0.11)。随访期间,治疗组和对照组心血管事件平均发生次数分别为0.26次和5.87次(p<0.01)。与非使用者相比,丹参酚酸注射液使用者的年平均费用低29.58%(4069.21元对5778.17元)。结论:我国冠心病心绞痛患者中,丹参酚酸注射液组心血管事件年发生率较低,心血管事件治疗费用较低。
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