The Protective Effect of Caffeic acid Phenethyl Ester on Cadmiyum-induced Liver Toxicity: A Histopathological and Biochemical Study

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Ankara Universitesi Veteriner Fakultesi Dergisi Pub Date : 2022-05-31 DOI:10.33988/auvfd.1068527

H. Deveci, G. Nur, A. Kükürt, M. Kuru, A. Deveci

引用次数: 1

Abstract

In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels and increased their TSA, LDL, TOC, and OSI levels. The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage.

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咖啡酸苯乙酯对镉致肝毒性的保护作用:组织病理学和生化研究

本研究探讨了咖啡酸苯乙酯(CAPE)对实验性镉中毒小鼠氧化/抗氧化平衡组织病理学和生化指标的影响。分析小鼠血浆对氧磷酶(PON)活性、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总唾液酸(TSA)、总抗氧化能力(TAC)、总氧化能力(TOC)和氧化应激指数(OSI)。结果表明，镉中毒引起小鼠氧化应激。它还降低了他们的PON活性、TAC和HDL水平，增加了他们的TSA、LDL、TOC和OSI水平。肝组织病理检查显示镉组肝组织出现局灶性凋亡区、窦状窦闭塞、不规则，其余各组无明显变化。这些结果表明，CAPE能显著预防镉损伤引起的生物化学和组织病理学变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ankara Universitesi Veteriner Fakultesi Dergisi 农林科学-兽医学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ankara Üniversitesi Veteriner Fakültesi Dergisi is one of the journals’ of Ankara University, which is the first well-established university in the Republic of Turkey. Research articles, short communications, case reports, letter to editor and invited review articles are published on all aspects of veterinary medicine and animal science. The journal is published on a quarterly since 1954 and indexing in Science Citation Index-Expanded (SCI-Exp) since April 2007.