Rational therapy for vaginal infections is a gynecologist’s choice

RMZh Mat'' i ditia Pub Date : 2022-01-01 DOI:10.32364/2618-8430-2022-5-1-41-45

M. Selikhova, T. I. Kostenko, A.A. Smol’yaninov

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Abstract

Vaginal discharge is the most common reason for referral to a gynecologist. Given the polyetiological nature of vaginal infections, broad- spectrum medications are selected for treatment. Antiseptic solutions (whose efficacy is similar to antibiotics) included in Russian clinical guidelines for obstetrics and gynecology are now more favored. Chlorohexidine is the most studied antiseptic solution with established efficacy in obstetrics and gynecology, whose hallmark is the lack of inhibiting effects on Lactobacilli and local immunity. Combining chlorohexidine and dexpanthenol is one of the most promising therapeutic tools for bacterial vaginosis and vaginal infections. Dexpanthenol stimulates reparation and recovering vaginal and cervical mucosal integrity. This property is crucial for reducing inflammation and preventing recurrences. Recent multicenter randomized and observational study results have demonstrated high efficacy, safety, and good tolerability of combined preparation for vulvovaginitis of different etiologies and vaginal dysbiosis in women of reproductive age, postmenopausal and pregnant women, and while breastfeeding. KEYWORDS: vaginal dysbiosis, vulvovaginitis, antiseptic, broad-spectrum, Lactobacilli, reparative. FOR CITATION: Selikhova M.S., Kostenko T.I., Smol’yaninov A.A. Rational therapy for vaginal infections is a gynecologist’s choice. Russian Journal of Woman and Child Health. 2022;5(1):41–45 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-41-45.

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阴道感染的合理治疗是妇科医生的选择

阴道分泌物是转介给妇科医生的最常见原因。鉴于阴道感染的多变性，选择广谱药物进行治疗。俄罗斯妇产科临床指南中包含的消毒溶液(其功效与抗生素相似)现在更受青睐。氯己定是妇产科研究最多、疗效确定的抗菌液，其特点是对乳酸菌和局部免疫缺乏抑制作用。氯己定与dexpanthenol联合治疗细菌性阴道病和阴道感染是最有前途的治疗手段之一。葡聚糖醇刺激修复和恢复阴道和宫颈粘膜的完整性。这种特性对减少炎症和防止复发至关重要。最近的多中心随机观察性研究结果表明，联合制剂对育龄妇女、绝经后妇女、孕妇和哺乳期间不同病因和阴道失调的外阴阴道炎具有较高的疗效、安全性和良好的耐受性。关键词:阴道生态失调，外阴阴道炎，抗菌，广谱，乳酸菌，修复。引文:Selikhova m.s.， Kostenko t.i.， Smol’yaninov A.A.。阴道感染的合理治疗是妇科医生的选择。俄罗斯妇幼卫生杂志，2022;5(1):41-45。DOI: 10.32364 / 2618-8430-2022-5-1-41-45。

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