Secondary Metabolites from Marine-Derived Fungus Aspergillus carneus GXIMD00519

Abstract

: Two new compounds, carneusins A-B ( 1-2 ), as well as fifteen known compounds ( 3-17 ), were isolated from the marine-derived fungus Aspergillus carneus GXIMD00519. Their structures were elucidated by the analysis of detailed spectroscopic data and quantum chemistry calculations. All the compounds were evaluated for their antibacterial, antibiofilm and cytotoxic effects. Compound 1 showed a moderate inhibitory effect against MRSA with the MIC value of 32 µg/mL. Compound 2 exhibited an anti-microfouling effect against biofouling bacterial Vibrio rotiferianus and Alteromonas macleodii with MIC value of 64 µg/mL. Compound 5 displayed antibiofilm activity against A. macleodii with the EC 50 value of 10.42 ± 0.58 µg/mL. Compounds 1 , 3 , 4 , 8 and 15 showed cytotoxicity against human pancreatic cancer cell lines SW1990, colorectal adenocarcinoma cell line DLD1, human pancreatic cancer cell line PANC1, and human hepatocellular carcinoma cell line Bel7402 with IC 50 values ranging of 2.75-17.77 µM.