{"title":"C-Reactive Protein in Idiopathic Inflammatory Myopathies","authors":"F. Hanisch, S. Zierz","doi":"10.3109/10582452.2013.852151","DOIUrl":null,"url":null,"abstract":"Abstract Objectives: To characterize C-reactive protein [CRP] in polymyositis [PM], dermatomyositis [DM], Jo-1 syndrome [Jo-1] and sporadic inclusion body myositis [sIBM]. Methods: C-reactive protein obtained before the start of immunosuppressive therapy was analyzed retrospectively in 61 therapy naïve patients [PM n = 27, DM n = 15, Jo-1 n = 5, sIBM n = 14]. All patients had a diagnosis of idiopathic inflammatory myopathy confirmed by muscle biopsy. Results: C-reactive protein was significantly higher in DM and Jo-1 compared to PM and sIBM [ANOVA p < 0.001]. The CRP levels less than twice the upper limit were found in 79% of sIBM patients, 85% of PM patients, 20% Jo-1 of patients, 53% of DM patients. C-reactive protein showed no correlation with creatine kinase and erythrocyte sedimentation rate. Conclusions: The CRP is elevated in a minority of patients with myositis, mostly associated with interstitial lung disease and malignancies.","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10582452.2013.852151","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Myopain","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10582452.2013.852151","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Abstract Objectives: To characterize C-reactive protein [CRP] in polymyositis [PM], dermatomyositis [DM], Jo-1 syndrome [Jo-1] and sporadic inclusion body myositis [sIBM]. Methods: C-reactive protein obtained before the start of immunosuppressive therapy was analyzed retrospectively in 61 therapy naïve patients [PM n = 27, DM n = 15, Jo-1 n = 5, sIBM n = 14]. All patients had a diagnosis of idiopathic inflammatory myopathy confirmed by muscle biopsy. Results: C-reactive protein was significantly higher in DM and Jo-1 compared to PM and sIBM [ANOVA p < 0.001]. The CRP levels less than twice the upper limit were found in 79% of sIBM patients, 85% of PM patients, 20% Jo-1 of patients, 53% of DM patients. C-reactive protein showed no correlation with creatine kinase and erythrocyte sedimentation rate. Conclusions: The CRP is elevated in a minority of patients with myositis, mostly associated with interstitial lung disease and malignancies.