What Do You Need to Know About GLP-1 Receptor Agonists?

Abstract

Glucagon-like peptide 1 (GLP-1) agonists are an important class of medications for patients with type 2 diabetes and should be considered for long-term therapy. A study of noninsulin treatment of type 2 diabetes in the United States showed that there has been a gradual decline in metformin use (from 57.0% in 2015 to 46.0% in 2019), an increase of GLP-1 agonist monotherapy use (from 4.3% in 2015 to 8.5% in 2019), and an increase in overall combined therapy use (from 9.8% in 2015 to 18.2% in 2019).1 Adequate management of diabetes with safe glycemic control is essential for reducing progression of chronic kidney disease, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD).