Protein C activity in dogs with gastric dilatation and volvulus

IF 0.6 4区农林科学 Q3 VETERINARY SCIENCES

Acta Veterinaria Brno Pub Date : 2022-01-01 DOI:10.2754/avb202291010035

A. Nečasová, Lucie Urbanova, Laura Staňková, Alena Pompová, Z. Filipejová, K. Somerlíková, K. Řeháková, A. Nečas

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引用次数: 1

Abstract

Protein C activity, a novel prognostic marker, was evaluated in patients with gastric dilatation and volvulus in relation to mortality and severity of the disease. Data on the mortality, duration of clinical signs, degree of gastric torsion, gastric necrosis, splenectomy and occurrence of disseminated intravascular coagulopathy were recorded. Blood samples were obtained at selected time periods: T0 = no longer than 30 min before surgery; T1 = first day after surgery; T2 = second day after surgery. In addition to protein C activity assessment, haematological and haemostaseological analysis was also performed. The mean protein C activity was the lowest at T1 and the highest at T2. No significant relationship between protein C activity and mortality, duration of clinical signs, degree of gastric torsion, gastric necrosis, splenectomy and disseminated intravascular coagulopathy was found in patients with gastric dilatation and volvulus. All patients that died during hospitalisation after surgery were patients with decreased protein C activity at T1. Although protein C activity was not found to be a reliable preoperative prognostic marker in patients with gastric dilatation and volvulus, the study results show it might be a promising marker in postoperative monitoring of these patients.

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胃扩张和胃扭转犬的蛋白C活性

蛋白C活性是一种新的预后标志物，在胃扩张和胃扭转患者中与死亡率和疾病严重程度的关系进行了评估。记录死亡率、临床症状持续时间、胃扭转程度、胃坏死、脾切除术和弥散性血管内凝血病的发生情况。在选定的时间段采集血样:T0 =手术前不超过30分钟;T1 =术后第一天;T2 =术后第2天。除了蛋白C活性评估外，还进行了血液学和血液学分析。平均蛋白C活性在T1时最低，在T2时最高。胃扩张和胃扭转患者的蛋白C活性与死亡率、临床症状持续时间、胃扭转程度、胃坏死、脾切除术和弥散性血管内凝血功能障碍无显著关系。所有术后住院期间死亡的患者均为T1时蛋白C活性降低的患者。虽然蛋白C活性并不是胃扩张和胃扭转患者术前预后的可靠指标，但研究结果表明，它可能是这些患者术后监测的一个有希望的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Veterinaria Brno 农林科学-兽医学

CiteScore

1.00

自引率

33.30%

发文量

审稿时长

18-36 weeks

期刊介绍： ACTA VETERINARIA BRNO is a scientific journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. The scientific journal Acta Veterinaria Brno is dedicated to the publication of original research findings and clinical observations in veterinary and biomedical sciences. Original scientific research articles reporting new and substantial contribution to veterinary science and original methods that have not been submitted for publication elsewhere are considered for publication. A written statement to this effect should accompany the manuscript, along with approval for publication by the author´s head of department. The authors bear full responsibility for the contents of their contribution. Book reviews are published, too.