PROSPECTS FOR THE USE OF DRUGS BASED ON BACTERIAL LIPOPOLYSACCHARIDES IN HEPATOLOGY

Abstract

Background. The study of new properties of bacterial lipopolysaccharides (BLPS), not related to their intoxication activity, is of great interest. Objective – to describe the mechanisms of BLPS action and to assess their effcacy. Material and methods. We performed a literature review of 32 sources published during the period from 1962 to 2020. Results. It was found out that in addition to the immunomodulatory effect, BLPS are capable of exerting anti-inflammatory, antitumor, radioprotective effects and stimulating tissue regeneration as well. A wide range of BLPS therapeutic effects has been established in diseases of the hepatobiliary system, as evidenced by experimental and clinical studies. BLPS administration shortens the manifestation stage of acute hepatitis, promotes quick normalization of functional liver tests and restoration of morphological changes in the liver. Conclusion. The presence of hepatoprotective and antifbrotic properties in BLPS encourages their wider use in clinical practice of hepatologists.