Antibacterial activity of metallic-core gold and silver nanoparticles against some animal pathogens

IF 1.8 4区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Annals of Animal Science Pub Date : 2023-02-07 DOI:10.2478/aoas-2023-0008

Adil Aksoy, Reem S. Alazragi, A. Alabdali, Raed Aljazzar, Salah El Sadi, M. Alostaz, Mahmoud El Hindi

{"title":"Antibacterial activity of metallic-core gold and silver nanoparticles against some animal pathogens","authors":"Adil Aksoy, Reem S. Alazragi, A. Alabdali, Raed Aljazzar, Salah El Sadi, M. Alostaz, Mahmoud El Hindi","doi":"10.2478/aoas-2023-0008","DOIUrl":null,"url":null,"abstract":"Abstract The current work aimed to find substitutes for antibiotics because of the side effects of antibacterial agents and the expansion of bacterial resistance to these agents. The scope of this study was to evaluate the antibacterial activity of gold and silver nanoparticles (AuNPs and AgNPs) against selected animal pathogens (Staphylococcus aureus, Klebsiella pneumonia, Streptococcus pneumoniae, Escherichia coli, Bacillus abortus and Mycobacterium bovis). The synthesized nanoparticles were distinguished by scanning electron microscopy (SEM) analysis and tested for antibacterial activity with the broth microdilution method, well diffusion assay, and minimum bactericidal concentration procedure. Results showed that both AuNPs and AgNPs displayed good antibacterial activity against all tested bacteria. The strongest antibacterial action of AgNPS (18 mm) was against E. coli. AuNPs displayed good antibacterial activity against S. aureus and B. bovis with a suppression area of 14 mm. Therefore, it is suggested that AgNPs and AuNPs could be effectively used against animal pathogens and may contribute to reducing antibiotic resistance. However, there is a need for further research on the in vivo toxicity and mechanisms of action of AuNPs and AgNPs.","PeriodicalId":8235,"journal":{"name":"Annals of Animal Science","volume":"23 1","pages":"473 - 479"},"PeriodicalIF":1.8000,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Animal Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2478/aoas-2023-0008","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract The current work aimed to find substitutes for antibiotics because of the side effects of antibacterial agents and the expansion of bacterial resistance to these agents. The scope of this study was to evaluate the antibacterial activity of gold and silver nanoparticles (AuNPs and AgNPs) against selected animal pathogens (Staphylococcus aureus, Klebsiella pneumonia, Streptococcus pneumoniae, Escherichia coli, Bacillus abortus and Mycobacterium bovis). The synthesized nanoparticles were distinguished by scanning electron microscopy (SEM) analysis and tested for antibacterial activity with the broth microdilution method, well diffusion assay, and minimum bactericidal concentration procedure. Results showed that both AuNPs and AgNPs displayed good antibacterial activity against all tested bacteria. The strongest antibacterial action of AgNPS (18 mm) was against E. coli. AuNPs displayed good antibacterial activity against S. aureus and B. bovis with a suppression area of 14 mm. Therefore, it is suggested that AgNPs and AuNPs could be effectively used against animal pathogens and may contribute to reducing antibiotic resistance. However, there is a need for further research on the in vivo toxicity and mechanisms of action of AuNPs and AgNPs.

查看原文本刊更多论文

金属核金、银纳米颗粒对某些动物病原体的抗菌活性

摘要当前的工作旨在寻找抗生素的替代品，因为抗菌药物的副作用和细菌对这些药物的耐药性扩大。本研究的范围是评估金纳米粒子和银纳米粒子(AuNPs和AgNPs)对选定的动物病原体(金黄色葡萄球菌、肺炎克雷伯菌、肺炎链球菌、大肠杆菌、流产芽孢杆菌和牛分枝杆菌)的抗菌活性。通过扫描电子显微镜(SEM)对合成的纳米颗粒进行了表征，并采用肉汤微稀释法、孔扩散法和最小杀菌浓度法对合成的纳米颗粒进行了抗菌活性测试。结果表明，AuNPs和AgNPs均具有良好的抑菌活性。AgNPS (18 mm)对大肠杆菌的抑菌作用最强。AuNPs对金黄色葡萄球菌和牛链球菌具有良好的抑菌活性，抑菌面积为14 mm。因此，AgNPs和AuNPs可以有效地用于动物病原体，并可能有助于减少抗生素耐药性。然而，AuNPs和AgNPs的体内毒性和作用机制还需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of Animal Science 农林科学-奶制品与动物科学

CiteScore

4.00

自引率

5.30%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Annals of Animal Science accepts original papers and reviews from the different topics of animal science: genetic and farm animal breeding, the biology, physiology and reproduction of animals, animal nutrition and feedstuffs, environment, hygiene and animal production technology, quality of animal origin products, economics and the organization of animal production.