Effect of Pentadecapeptide BPC 157 on Hemodynamic and ECG Disorders Caused by Sotalol in Wistar Albino Rats

Abstract

were noted, along with the decrease in abdominal aortic pressure (52 ± 2 mmHg). These effects were attenuated in BPC treated animals (-2 ± 1 mmHg for superior sagittal sinus, 6 ± 1 mmHg in portal vein, 5 ± 1 mmHg in inferior caval vein, and 83 ± 2 mmHg in abdominal aorta). CONCLUSION: In summary, BPC 157 attenuated detrimental hemodynamic effects of sotalol while the effects on ECG parameters were also noted, but not as lasting, as hemodynamic ones, supporting the view of BPC 157 as a rapid-acting protective agent.