Infection, Inflammation and Immunity in Covid-19 Infection

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2021-10-01 DOI:10.2478/amb-2021-0040

R. Cherneva, Z. Cherneva

引用次数: 0

Abstract

Abstract The COVID-19 pandemic caused by the SARS-CoV-2 has increased the burden on healthcare system. Despite some progress in its diagnostics has been made, effective prevention and treatment are still insufficient. Since SARS-CoV-2 infections often cause systemic inflammation and multiple organ failure, the therapeutic options aimed at modulating the host immune responses to prevent subsequent systemic complications are demanding. The review provides a summary of the SARS-CoV-2 virus infection and underlines the current perception of pulmonary host’s immune response and its contributions to disease severity and systemic inflammation. Signaling pathways which have the potential to manipulate host immunity and improve clinical outcomes are also presented.

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Covid-19感染中的感染、炎症和免疫

由SARS-CoV-2引起的COVID-19大流行增加了卫生保健系统的负担。尽管在诊断方面取得了一些进展，但有效的预防和治疗仍然不足。由于SARS-CoV-2感染通常会导致全身性炎症和多器官衰竭，因此旨在调节宿主免疫反应以防止随后的全身并发症的治疗方案要求很高。该综述概述了SARS-CoV-2病毒感染，并强调了目前对肺宿主免疫反应及其对疾病严重程度和全身性炎症的影响的认识。有可能操纵宿主免疫和改善临床结果的信号通路也被提出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.