РОЛЬ ГАЛЕКТИНА-3 И ЭПИКАРДИАЛЬНОГО ЖИРА В РАЗВИТИИ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙ ПРИ МЕТАБОЛИЧЕСКОМ СИНДРОМЕ

Ucenye Zapiski SanktPeterburgskogo Gosudarstvennogo Medicinskogo Universiteta im Akad IP Pavlova Pub Date : 2015-01-01 DOI:10.24884/1607-4181-2015-22-1-43-46

V. Ionin, O. V. Listopad, S. E. Nifontov, E. I. Baranova, A. Soboleva, E. Shlyakhto

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引用次数: 3

Abstract

Objective. To evaluate the epicardial fat thickness (EFT) in patients with metabolic syndrome (MS), including paroxysmal and persistent atrial fibrillation (AF). To relate EFT to the fibroid heart marker, i.e. galectin 3. Materials and methods. We examined 100 patients with MS (50 with AF), and 50 healthy persons made the control group. Serum galectin 3 was measured by ELISA method. The EFT was measured with echocardiography. Results. EFT in patients with MS was twofold higher than in healthy persons. EFT in patients with MS and AF didn't differ significantly from that in patients with MS without AF. Positive correlation between the levels of EFT and galectin 3 in serum was revealed. Serum galectin 3 and EFT were associated with atrial fibrillation in patients with MS (OR:1,27, 95% CI 1,02-1,58 and OR:1,73, 95% CI 1,37-2,19, correspondingly).Conclusion. Definition of EFT at echocardiography can be used in the assessment of risk AF in patients with MS.

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galectine -3和外质脂肪在新陈代谢综合征心房颤动发育中的作用

目标。评价代谢综合征(MS)患者的心外膜脂肪厚度(EFT)，包括阵发性和持续性心房颤动(AF)。将EFT与肌瘤心脏标志物，即凝集素3联系起来。材料和方法。我们检查了100例多发性硬化症患者(其中50例合并房颤)，50例健康人作为对照组。ELISA法测定血清凝集素3。超声心动图测量EFT。结果。多发性硬化症患者的EFT是健康人的两倍。伴有多发性硬化症和房颤的患者的EFT与不伴有房颤的多发性硬化症患者的EFT差异无统计学意义，EFT水平与血清凝集素3呈正相关。血清凝集素3和EFT与MS患者房颤相关(OR:1,27, 95% CI 1,02-1,58; OR:1,73, 95% CI 1,37-2,19)。超声心动图中EFT的定义可用于MS患者房颤风险的评估。

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Ucenye Zapiski SanktPeterburgskogo Gosudarstvennogo Medicinskogo Universiteta im Akad IP Pavlova

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8 weeks