Optimal feed temperature for hydrogen peroxide decomposition process occurring in a bioreactor with fixed-bed of commercial catalase: a case study on thermal deactivation of the enzyme

IF 0.5 4区工程技术 Q4 ENGINEERING, CHEMICAL

Chemical and Process Engineering-Inzynieria Chemiczna I Procesowa Pub Date : 2023-11-06 DOI:10.24425/CPE.2018.124974

I. Grubecki

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引用次数: 1

Abstract

On the basis of hydrogen peroxide decomposition process occurring in the bioreactor with fixed-bed of commercial catalase the optimal feed temperature was determined. This feed temperature was obtained by maximizing the time-average substrate conversion under constant feed flow rate and temperature constraints. In calculations, convection-diffusion-reaction immobilized enzyme fixed-bed bioreactor described by a coupled mass and energy balances as well as general kinetic equation for rate of enzyme deactivation was taken into consideration. This model is based on kinetic, hydrodynamic and mass-transfer parameters estimated in earlier work. The simulation showed that in the biotransformation with thermal deactivation of catalase optimal feed temperature is only affected by kinetic parameters for enzyme deactivation and decreases with increasing value of activation energy for deactivation. When catalase undergoes parallel deactivation the optimal feed temperature is strongly dependent on hydrogen peroxide feed concentration, feed flow rate and diffusional resistances expressed by biocatalyst effectiveness factor. It has been shown that the more significant diffusional resistances and the higher hydrogen peroxide conversions, the higher the optimal feed temperature is expected.

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过氧化氢酶固定床生物反应器中过氧化氢分解过程的最佳进料温度——以过氧化氢酶热失活为例

根据过氧化氢酶固定床生物反应器中过氧化氢分解过程，确定了最佳进料温度。该进料温度是通过在恒定进料流量和温度约束下最大化时间平均底物转化率而获得的。在计算中，考虑了对流-扩散-反应固定化酶固定床生物反应器的质量和能量耦合平衡以及酶失活速率的一般动力学方程。该模型基于早期工作中估计的动力学、流体力学和传质参数。模拟结果表明，在过氧化氢酶热失活生物转化过程中，最佳饲料温度只受酶失活动力学参数的影响，并随着失活活化能的增大而降低。过氧化氢酶平行失活时，最佳进料温度与过氧化氢进料浓度、进料流量和生物催化剂效能因子表达的扩散阻力密切相关。结果表明，扩散阻力越大，过氧化氢转化率越高，期望的最佳进料温度越高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical and Process Engineering-Inzynieria Chemiczna I Procesowa 工程技术-工程：化工

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The content, aim and scope of the proposals should comply with the main subject of the journal, i.e. they should deal with mathematical modelling and/or experimental investigations on momentum, heat and mass transfer, unit processes and operations, integrated processes, biochemical engineering, statics and kinetics of chemical reactions. The experiments and modelling may cover different scales and processes ranging from the molecular phenomena up to production systems. The journal language is grammatically correct British English. Chemical and Process Engineering publishes: i) full text research articles, ii) invited reviews, iii) letters to the editor and iv) short communications, aiming at important new results and/or applications. Each of the publication form is peer-reviewed by at least two independent referees.