X-irradiation protection studies. II. Modification of the radiation syndrome in female DAL-Swiss mice by AET and 5-HT.

Abstract

Previously (1) it was shown that survival-time curves are influenced by the irradiation rate and should be statistically analyzed at a probability level of 0.02 because of the inherent biological variations. The protective action of AET (2aminoethylisothiuronium-bromide hydrobromide) has been reported in mice (29), in rats (3), and in monkeys (10). However, Benson et al. (11) were unable to confirm its protective action in dogs. Mice (12-14) and rats (15, 16) have been