The respective effects of ethyl alcohol and grape polyphenols upon the morphological index of rat kidneys

Abstract

BackgroundWe studied the individual effect of ethyl alcohol and food extract of polyphenols from grapes “Enoant” onthe single kidney following one-sided left nephrectomy. The aim of our research was to study tendencies in the compensatory — adaptation processes of a single kidney after administration of ethyl alcohol or “Enoant” respectively into experimental animals (white rats) following single nephrectomy.Materials and methodsIn total n=27 white rats (males and females) were used at the age of 3 months and weighing from 160g to 200g. Rats were kept under standard conditions according to the recommendations of Zapadnyuk et al (1983) and divided into three groups. All animals in this study underwent unilateral nephrectomy only The 1st experimental group of animals received ethyl alcohol post-operatively (every day, by gavage. The ethyl alcohol was given in proportion to their body weight-0.005 ml of the 40% ethyl alcohol to every 1 gram of the rat’s weight. In a 2nd experimental group) — animals received Enoant (again using a gastric tube and in proportion to the animal’s body weight, i.e. 0.5 ml/kg).ResultsWhen identifying effects of the ethyl alcohol and “Enoant”on the tissues of a single kidney, (left after a one-sided nephrectomy), it was found that introduction of an agent such as ethyl alcohol interferes with the enzyme activity associated with internal respiration, both acute and chronic alcohol intoxication.ConclusionThe introduction of ethyl alcohol into rats infringed on the microcirculation processes in the tissues of single kidney. Indicated processes have delayed the rate of development and level of compensational hypertrophy in all parts of the renal tube of the kidney, left after the unilateral nephrectomy. Further, introduction of polyphenols from grapes into experimental animals accelerate the speed and level of compensatory hypertrophy of the kidney during the time of experiment. Further, the administration of Enoant accelerated the speed and level of the compensatory hypertrophy of the kidney in the studied rats.