Rutin: a Flavonoid Precursor for Synthesis of ZnFe2O4 Nanoparticles; Electrochemical Study of Zinc Ferrite-chitosan Nanogel for Doxorubicin Delivery

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
Mostafa Shafiee, S. H. Ghoran, S. Bordbar, M. Gholami, M. Naderian, Fatemeh Dehghani, A. Amani
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引用次数: 1

Abstract

The use of core-shell nanoparticles as controlled drug delivery vehicles has proven successful, yet their production and application require costly and toxic chemicals. We hereby use a natural glycosylated flavonoid (rutin) for synthesis of a nanocarrier for doxorubicin delivery. For this target, a convenient two-step synthesis was processed including a synthesis of bio-zinc ferrite nanoparticles without N2 gas and chitosan coating (CS; bio-zincferrite@chitosan). The as-synthesized magnetic nanogel was characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transformed infrared (FT-IR) spectroscopy, and electro-analytical methods including cyclic voltammetry and electrochemical impedance spectroscopies. The collapse/swell potential of the coated CS layers of the bio-NPs were found to be responsible for the observed pH dependence of doxorubicin delivery. Results exhibited the drug release of bio-nanogel can be induced at pH ranging from 6 to 7. Therefore, capacity and efficiency parameters of the anti-cancer drug onto the NPs were obtained as equal to 43.5% and 78.6%. The present work provides a simple method to fabricate smart pH-responsive nanogel for cancer therapy.
合成纳米ZnFe2O4的类黄酮前体芦丁铁酸锌-壳聚糖纳米凝胶递送阿霉素的电化学研究
核壳纳米粒子作为受控药物递送载体的使用已被证明是成功的,但它们的生产和应用需要昂贵和有毒的化学品。我们在此使用一种天然糖基化的类黄酮(芦丁)合成了一种用于阿霉素递送的纳米载体。针对这一目标,采用了两步合成方法:无N2气合成生物铁氧体锌纳米颗粒,壳聚糖包覆(CS;bio-zincferrite@chitosan)。利用扫描电子显微镜(SEM)、透射电子显微镜(TEM)、傅里叶变换红外光谱(FT-IR)以及循环伏安法和电化学阻抗谱等电分析方法对合成的磁性纳米凝胶进行了表征。发现生物nps包被的CS层的坍塌/膨胀电位是观察到的阿霉素递送的pH依赖性的原因。结果表明,pH为6 ~ 7时,生物纳米凝胶可诱导药物释放。因此,得到的抗癌药物在NPs上的容量和效率参数分别为43.5%和78.6%。本研究提供了一种制备用于癌症治疗的智能ph响应纳米凝胶的简单方法。
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来源期刊
Journal of Nanostructures
Journal of Nanostructures NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
2.60
自引率
0.00%
发文量
0
审稿时长
7 weeks
期刊介绍: Journal of Nanostructures is a medium for global academics to exchange and disseminate their knowledge as well as the latest discoveries and advances in the science and engineering of nanostructured materials. Topics covered in the journal include, but are not limited to the following: Nanosystems for solar cell, energy, catalytic and environmental applications Quantum dots, nanocrystalline materials, nanoparticles, nanocomposites Characterization of nanostructures and size dependent properties Fullerenes, carbon nanotubes and graphene Self-assembly and molecular organization Super hydrophobic surface and material Synthesis of nanostructured materials Nanobiotechnology and nanomedicine Functionalization of nanostructures Nanomagnetics Nanosensors.
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