Mostafa Shafiee, S. H. Ghoran, S. Bordbar, M. Gholami, M. Naderian, Fatemeh Dehghani, A. Amani
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引用次数: 1
Abstract
The use of core-shell nanoparticles as controlled drug delivery vehicles has proven successful, yet their production and application require costly and toxic chemicals. We hereby use a natural glycosylated flavonoid (rutin) for synthesis of a nanocarrier for doxorubicin delivery. For this target, a convenient two-step synthesis was processed including a synthesis of bio-zinc ferrite nanoparticles without N2 gas and chitosan coating (CS; bio-zincferrite@chitosan). The as-synthesized magnetic nanogel was characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transformed infrared (FT-IR) spectroscopy, and electro-analytical methods including cyclic voltammetry and electrochemical impedance spectroscopies. The collapse/swell potential of the coated CS layers of the bio-NPs were found to be responsible for the observed pH dependence of doxorubicin delivery. Results exhibited the drug release of bio-nanogel can be induced at pH ranging from 6 to 7. Therefore, capacity and efficiency parameters of the anti-cancer drug onto the NPs were obtained as equal to 43.5% and 78.6%. The present work provides a simple method to fabricate smart pH-responsive nanogel for cancer therapy.
期刊介绍:
Journal of Nanostructures is a medium for global academics to exchange and disseminate their knowledge as well as the latest discoveries and advances in the science and engineering of nanostructured materials. Topics covered in the journal include, but are not limited to the following: Nanosystems for solar cell, energy, catalytic and environmental applications Quantum dots, nanocrystalline materials, nanoparticles, nanocomposites Characterization of nanostructures and size dependent properties Fullerenes, carbon nanotubes and graphene Self-assembly and molecular organization Super hydrophobic surface and material Synthesis of nanostructured materials Nanobiotechnology and nanomedicine Functionalization of nanostructures Nanomagnetics Nanosensors.