Adjuvant chemotherapy of resistant high risk choriocarcinoma

Q4 Medicine
Tamara Djuricic, A. Mandić, B. Gutic, Natasa Prvulovic-Bunovic, N. Stanulovic
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引用次数: 1

Abstract

Choriocarcinoma is a subtype of gestational trophoblastic disease. It is a very rare neoplasm, with incidence of about 1 case in 40.000 pregnancies. Gestational form of choriocarcinoma arises most commonly after abortion, while nongestational form develops from pluripotent germ cells. Choricarcinoma is highly malignant and highly chemosensitive type of tumor. A 43-year-old patient diagnosed with extra uterine pregnancy in September 2017 was treated with methotrexate with no response and had surgical removal of right Fallopian tube. Choriocarcinoma was diagnosed one and a half year after extra uterine pregnancy. Radiological imaging before treatment showed pulmonary and inguinal lymph node metastases and tumor invasion of the anterior uterine wall. Surgery was performed due to heavy bleeding and uterine wall invasion. As high risk patient she received chemotherapy. She was followed radiologically and her serum ?-HCG was monitored. Refractivity to the chemotherapy protocol during treatment was observed. Therapy response was achieved after administration of EMA-EP protocol modification i.e. three consecutive negative follow-up values of ?-HCG were obtained and radiological findings were disease free. One month after treatment patient had no signs of disease and ?-HCG level was normal.
耐药高危绒毛膜癌的辅助化疗
绒毛膜癌是妊娠滋养细胞疾病的一种亚型。这是一种非常罕见的肿瘤,发病率约为40000例妊娠中1例。妊娠期绒毛膜癌最常见于流产后,而非妊娠期绒毛膜癌则由多能生殖细胞发展而来。绒毛膜癌是一种高度恶性、高度化学敏感性的肿瘤。43岁患者于2017年9月确诊为子宫外妊娠,经甲氨蝶呤治疗无效,手术切除右侧输卵管。绒毛膜癌是在子宫外妊娠一年半后确诊的。治疗前影像学显示肺及腹股沟淋巴结转移及肿瘤侵袭子宫前壁。因大出血及子宫壁受侵犯而行手术。作为高危患者,她接受了化疗。对她进行了放射学随访并监测了她的血清-HCG。观察治疗期间对化疗方案的折光性。在修改EMA-EP方案后获得治疗效果,即连续三次获得-HCG阴性随访值,影像学结果无疾病。治疗1个月后,患者无疾病症状,-HCG水平正常。
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来源期刊
Archive of Oncology
Archive of Oncology Medicine-Oncology
CiteScore
0.60
自引率
0.00%
发文量
5
审稿时长
12 weeks
期刊介绍: Archive of Oncology is an international oncology journal that publishes original research, editorials, review articles, case (clinical) reports, and news from oncology (medical, surgical, radiation), experimental oncology, cancer epidemiology, and prevention. Letters are also welcomed. Archive of Oncology is covered by Biomedicina Vojvodina, Biomedicina Serbica, Biomedicina Oncologica, EMBASE/Excerpta Medica, ExtraMED and SCOPUS.
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