Tumor budding in cervical carcinoma: Associations with some clinical and pathological factors

Q4 Medicine
N. Stanulovic, T. Ivković-Kapicl, A. Mandić, B. Gutic
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引用次数: 1

Abstract

Background: Tumor budding is recognized as an important independent prognostic factor in colorectal carcinoma. The aim of this study was to evaluate the grade of tumor budding and association with other clinical and pathological features in patients with cervical carcinoma. Material and methods: We evaluated pathohistological data from 91 cervical carcinoma patients (mean age: 53.8 years) who underwent radical hysterectomy and pelvic lymphatic dissection at the Oncology Institute of Vojvodina between January 2010 and December 2018. Tumor budding was evaluated in invasive front of the tumor. Based on the number of bud counts/10 high power field, three groups were formed: with no budding, with less than 15 buds, and with more than 15 buds. Results: Eighty (87.91%) of evaluated cervical carcinomas were squamous-cell type, while 12.09% were adenocarcinomas. All carcinomas were graded (HG1-HG3). Average diameter of the tumors was 25 mm (81.6% < 4 cm and 18.4% > 4 cm). Metastases in lymph nodes were present in 30 (32.9%) cases. Based on the number of bud counts/10 high power field there were 35.1% with no budding, 32.9% with less than 15 buds and 37.3% with more than 15 buds. There was a significant association between tumor budding grade and histological grade (p=0.04), as well as with tumor budding grade and the diameter of the tumor (p=0.04). Conclusion: As a quantitative measure of cancer cell dissociation, tumor budding is associated with poor prognosis in cervical carcinoma and should be considered as a prognostic factor.
宫颈癌肿瘤出芽:与一些临床和病理因素的关系
背景:肿瘤出芽被认为是结直肠癌重要的独立预后因素。本研究的目的是评估宫颈癌患者肿瘤出芽的分级及其与其他临床和病理特征的关系。材料和方法:我们评估了2010年1月至2018年12月期间在伏伊伏丁那肿瘤研究所接受根治性子宫切除术和盆腔淋巴清扫的91例宫颈癌患者(平均年龄:53.8岁)的病理组织学资料。在肿瘤侵袭性前方评估肿瘤出芽。根据芽数/10高倍场分为无芽、芽数小于15和芽数大于15三组。结果:80例(87.91%)宫颈癌为鳞状细胞型,12.09%为腺癌。所有肿瘤分级(HG1-HG3)。肿瘤平均直径为25mm (< 4cm占81.6%,< 4cm占18.4%)。淋巴结转移30例(32.9%)。从芽数/10高倍场来看,未出芽的占35.1%,少于15芽的占32.9%,大于15芽的占37.3%。肿瘤出芽分级与组织学分级有显著相关性(p=0.04),与肿瘤出芽分级和肿瘤直径有显著相关性(p=0.04)。结论:肿瘤出芽作为癌细胞游离的定量指标,与宫颈癌预后不良有关,应作为预后因素考虑。
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来源期刊
Archive of Oncology
Archive of Oncology Medicine-Oncology
CiteScore
0.60
自引率
0.00%
发文量
5
审稿时长
12 weeks
期刊介绍: Archive of Oncology is an international oncology journal that publishes original research, editorials, review articles, case (clinical) reports, and news from oncology (medical, surgical, radiation), experimental oncology, cancer epidemiology, and prevention. Letters are also welcomed. Archive of Oncology is covered by Biomedicina Vojvodina, Biomedicina Serbica, Biomedicina Oncologica, EMBASE/Excerpta Medica, ExtraMED and SCOPUS.
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